DoseFinding: Planning and Analyzing Dose Finding Experiments

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).

Version:	1.1-1
Depends:	ggplot2, lattice, mvtnorm, R (≥ 2.15.0)
Suggests:	numDeriv, Rsolnp, quadprog, parallel, multcomp, knitr, rmarkdown, MASS, testthat, RBesT
Published:	2023-11-02
Author:	Bjoern Bornkamp [aut, cre], Jose Pinheiro [aut], Frank Bretz [aut], Ludger Sandig [aut], Marius Thomas [aut]
Maintainer:	Bjoern Bornkamp <bjoern.bornkamp at novartis.com>
License:	GPL-3
NeedsCompilation:	yes
Materials:	ChangeLog
In views:	ClinicalTrials, ExperimentalDesign
CRAN checks:	DoseFinding results

Documentation:

Reference manual:	DoseFinding.pdf
Vignettes:	Analysis template MCP-Mod for continuous data Design and analysis template MCP-Mod for binary data Frequently Asked Questions for MCP-Mod Analysis template: MCP-Mod with multiple regimen Overview DoseFinding package Sample size template for MCP-Mod for normally distributed data

Downloads:

Package source:	DoseFinding_1.1-1.tar.gz
Windows binaries:	r-devel: DoseFinding_1.1-1.zip, r-release: DoseFinding_1.1-1.zip, r-oldrel: DoseFinding_1.1-1.zip
macOS binaries:	r-release (arm64): DoseFinding_1.1-1.tgz, r-oldrel (arm64): DoseFinding_1.1-1.tgz, r-release (x86_64): DoseFinding_1.1-1.tgz, r-oldrel (x86_64): DoseFinding_1.1-1.tgz
Old sources:	DoseFinding archive

Reverse dependencies:

Reverse depends:	MCPModGeneral, TestingSimilarity
Reverse imports:	BayesianMCPMod, clinDR, dosedesignR, LRcontrast, MCPModBC, uniReg
Reverse suggests:	MCPModPack

Linking:

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