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hesim: Health Economic Simulation Modeling and Decision Analysis

A modular and computationally efficient R package for parameterizing, simulating, and analyzing health economic simulation models. The package supports cohort discrete time state transition models (Briggs et al. 1998) <doi:10.2165/00019053-199813040-00003>, N-state partitioned survival models (Glasziou et al. 1990) <doi:10.1002/sim.4780091106>, and individual-level continuous time state transition models (Siebert et al. 2012) <doi:10.1016/j.jval.2012.06.014>, encompassing both Markov (time-homogeneous and time-inhomogeneous) and semi-Markov processes. Decision uncertainty from a cost-effectiveness analysis is quantified with standard graphical and tabular summaries of a probabilistic sensitivity analysis (Claxton et al. 2005, Barton et al. 2008) <doi:10.1002/hec.985>, <doi:10.1111/j.1524-4733.2008.00358.x>. Use of C++ and data.table make individual-patient simulation, probabilistic sensitivity analysis, and incorporation of patient heterogeneity fast.

Version: 0.5.4
Depends: R (≥ 3.5.0)
Imports: data.table, flexsurv, ggplot2, MASS, msm, Rcpp (≥ 0.12.16), R6, stats, survival
LinkingTo: Rcpp, RcppArmadillo
Suggests: covr, kableExtra, knitr, magrittr, mstate, nnet, numDeriv, pracma, rmarkdown, scales, testthat, truncnorm
Published: 2024-02-12
Author: Devin Incerti [aut, cre], Jeroen P. Jansen [aut], Mark Clements [aut], R Core Team [ctb] (hesim uses some slightly modified C functions from base R)
Maintainer: Devin Incerti <devin.incerti at gmail.com>
BugReports: https://github.com/hesim-dev/hesim/issues
License: GPL-3
URL: https://hesim-dev.github.io/hesim/, https://github.com/hesim-dev/hesim
NeedsCompilation: yes
Citation: hesim citation info
Materials: README
CRAN checks: hesim results

Documentation:

Reference manual: hesim.pdf
Vignettes: Cost-effectiveness analysis
Introduction to 'hesim'
Simple Markov cohort model
Time inhomogeneous Markov cohort models
Time inhomogeneous Markov individual-level models
Markov models with multinomial logistic regression
Markov and semi-Markov multi-state models
Partitioned survival models

Downloads:

Package source: hesim_0.5.4.tar.gz
Windows binaries: r-devel: hesim_0.5.4.zip, r-release: hesim_0.5.4.zip, r-oldrel: hesim_0.5.4.zip
macOS binaries: r-release (arm64): hesim_0.5.4.tgz, r-oldrel (arm64): hesim_0.5.4.tgz, r-release (x86_64): hesim_0.5.4.tgz, r-oldrel (x86_64): hesim_0.5.4.tgz
Old sources: hesim archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=hesim to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.