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The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.
| Version: | 1.1.3 |
| Depends: | R (≥ 3.5.0) |
| Imports: | corpcor, data.table, dplyr, gsDesign, gt, methods, mvtnorm, npsurvSS (≥ 1.1.0), r2rtf, stats, survival, tibble, tidyr, utils, Rcpp |
| LinkingTo: | Rcpp |
| Suggests: | covr, ggplot2, kableExtra, knitr, rmarkdown, simtrial, testthat (≥ 3.0.0) |
| Published: | 2024-11-15 |
| DOI: | 10.32614/CRAN.package.gsDesign2 |
| Author: | Keaven Anderson [aut], Yilong Zhang [aut], Yujie Zhao [aut, cre], Jianxiao Yang [aut], Nan Xiao [aut], Amin Shirazi [ctb], Ruixue Wang [ctb], Yi Cui [ctb], Ping Yang [ctb], Xin Tong Li [ctb], Chenxiang Li [ctb], Hiroaki Fukuda [ctb], Hongtao Zhang [ctb], Yalin Zhu [ctb], John Blischak [ctb], Dickson Wanjau [ctb], Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph] |
| Maintainer: | Yujie Zhao <yujie.zhao at merck.com> |
| BugReports: | https://github.com/Merck/gsDesign2/issues |
| License: | GPL-3 |
| URL: | https://merck.github.io/gsDesign2/, https://github.com/Merck/gsDesign2 |
| NeedsCompilation: | yes |
| Materials: | README NEWS |
| CRAN checks: | gsDesign2 results |
| Reference manual: | gsDesign2.pdf |
| Vignettes: |
Quick start for NPH sample size and power (source, R code) |
| Package source: | gsDesign2_1.1.3.tar.gz |
| Windows binaries: | r-devel: gsDesign2_1.1.3.zip, r-release: gsDesign2_1.1.3.zip, r-oldrel: gsDesign2_1.1.3.zip |
| macOS binaries: | r-release (arm64): gsDesign2_1.1.3.tgz, r-oldrel (arm64): gsDesign2_1.1.3.tgz, r-release (x86_64): gsDesign2_1.1.3.tgz, r-oldrel (x86_64): gsDesign2_1.1.3.tgz |
| Old sources: | gsDesign2 archive |
| Reverse imports: | simtrial |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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