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Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the 'Efftox' (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.
| Version: | 1.5 |
| Imports: | Rcpp (≥ 0.12.18), mvtnorm |
| LinkingTo: | Rcpp, RcppArmadillo |
| Published: | 2020-07-31 |
| DOI: | 10.32614/CRAN.package.Phase12Compare |
| Author: | Andrew G Chapple |
| Maintainer: | Andrew G Chapple <achapp at lsuhsc.edu> |
| License: | GPL-2 |
| NeedsCompilation: | yes |
| CRAN checks: | Phase12Compare results |
| Reference manual: | Phase12Compare.pdf |
| Package source: | Phase12Compare_1.5.tar.gz |
| Windows binaries: | r-devel: Phase12Compare_1.5.zip, r-release: Phase12Compare_1.5.zip, r-oldrel: Phase12Compare_1.5.zip |
| macOS binaries: | r-release (arm64): Phase12Compare_1.5.tgz, r-oldrel (arm64): Phase12Compare_1.5.tgz, r-release (x86_64): Phase12Compare_1.5.tgz, r-oldrel (x86_64): Phase12Compare_1.5.tgz |
| Old sources: | Phase12Compare archive |
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