PFIM: Population Fisher Information Matrix
Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>, Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>, Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>, Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>, Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.
| Version: | 7.0 |
| Depends: | R (≥ 4.0.0) |
| Imports: | utils, inline, Deriv, methods, deSolve, purrr, stringr, S7, Matrix, ggplot2, Rcpp, RcppArmadillo, pracma, kableExtra, tibble, scales, knitr |
| Suggests: | rmarkdown, testthat (≥ 3.0.0) |
| Published: | 2025-07-02 |
| DOI: | 10.32614/CRAN.package.PFIM |
| Author: | Romain Leroux 
[aut, cre],
France Mentré
[aut],
Jérémy Seurat
[ctb] |
| Maintainer: | Romain Leroux <romainlerouxPFIM at gmail.com> |
| BugReports: | https://github.com/packagePFIM/PFIM/issues |
| License: | GPL (≥ 3) |
| URL: | http://www.pfim.biostat.fr/, https://github.com/packagePFIM |
| NeedsCompilation: | no |
| Citation: | PFIM citation info |
| Materials: | NEWS |
| CRAN checks: | PFIM results |
Documentation:
| Reference manual: | PFIM.pdf |
| Vignettes: |
Design evaluation and optimization in discrete space (source, R code) Design evaluation and optimization in continuous space (source, R code) Library of models (source, R code) |
Downloads:
| Package source: | PFIM_7.0.tar.gz |
| Windows binaries: | r-devel: PFIM_7.0.zip, r-release: PFIM_7.0.zip, r-oldrel: PFIM_7.0.zip |
| macOS binaries: | r-release (arm64): PFIM_7.0.tgz, r-oldrel (arm64): PFIM_7.0.tgz, r-release (x86_64): PFIM_7.0.tgz, r-oldrel (x86_64): PFIM_7.0.tgz |
| Old sources: | PFIM archive |
Linking:
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