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PFIM 7.0 – What’s New

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This version fully replaces the version of PFIM 6.1

Complete Package Redesign

Functional Programming Architecture: Version 7.0 is entirely rebuilt using functional programming principles for improved performance and maintainability.
Breaking Changes: This version introduces significant user script changes that require script updates from previous versions
Enhanced Features: New modeling capabilities and improved Bayesian FIM estimation

Key New Features

Flexible PK/PD Modeling: Support for multiple PK responses with PD components (ode pk pk pk .. pd)
Expanded User Defined Model: Additional models available (see BJCP test in https://github.com/packagePFIM)
Bayesian FIM Estimation: Enhanced estimation for single sampling time scenarios
Multi-dose Bolus Models: New ODE-based multi-dose bolus modeling capabilities

Migration Guide from PFIM 6.1 to PFIM 7.0

1. Equations of a user defined model

PFIM 6.1:

{r, echo = TRUE, comment='',eval=FALSE} modelEquations` = `list( outcomes = list( "RespPK", "RespPD" ), equations = list( "RespPK" = "dose_RespPK/V * ka/( ka - Cl/V ) * ( exp( -Cl/V *t ) - exp(-ka * t ) )", "RespPD" = "S0 * ( 1 - Imax * RespPK/( RespPK + C50 ) )" ) ) - PFIM 7.0: {r, echo = TRUE, comment='',eval=FALSE} modelEquations = list( "RespPK" = "dose_RespPK/V * ka/( ka - Cl/V )*( exp( -Cl/V * t ) - exp( -ka * t ) )", "RespPD" = "S0 * ( 1 - Imax * RespPK/( RespPK + C50 ) )" )

2. Model equations from the library of models.

PFIM 7.0 introduces modelFromLibrary for predefined models:

{r, echo = TRUE, comment='',eval=FALSE} modelFromLibrary = list( "PKModel" = "MichaelisMenten2InfusionSingleDose_VmKmk12k21V1V2", "PDModel" = "TurnoverRinEmax_RinEmaxCC50koutE" )

and the evaluation writes:

{r, echo = TRUE, comment='',eval=FALSE} evaluation = Evaluation( modelFromLibrary = modelFromLibrary, ... )

without the slots modelEquations.

3. Model error

The outcome od an error model is modified.

PFIM 6.1: outcomes
PFIM 7.0: outputs

4. Arm

The specification of the dose in the initial conditions for an ode model is modified.

PFIM 6.1: initialCondition = list( "C1" = "dose" )
PFIM 7.0: initialCondition = list( "C1" = "dose_C1" )

5. Administration constraints

The constraints for the administration for the design optimization is changed.

PFIM 6.1 (vector): doses = c( 0.2, 0.64, 2, 6.24, 11.24, 20 )
PFIM 7.0 (list): doses = list( 0.2, 0.64, 2, 6.24, 11.24, 20 )

6. Evaluation

The evaluation outcomes are changed.

PFIM 6.1: outcomes = list( "RespPK" )
PFIM 7.0: outputs = list( "RespPK" )

The specification of the Fim type is changed.

PFIM 6.1: fim = " ... "\
PFIM 7.0 fimType = " ... "

7. Output methods

The plot method for the sensitivity indices is changed.

PFIM 6.1: plotSensitivityIndice = plotSensitivityIndice( ..., ... )
PFIM 7.0: plotSensitivityIndices = plotSensitivityIndices( ..., ... )
Correlation matrix removed from report in this version
SE and RSE extraction simplified with direct access without [[designName]] indexing

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.