simIDM: Simulating Oncology Trials using an Illness-Death Model

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

Version:	0.1.0
Depends:	R (≥ 3.6)
Imports:	checkmate, furrr, future, mstate, parallelly, stats, survival
Suggests:	coxphw, knitr, mvna, prodlim, rmarkdown, rpact, testthat (≥ 3.0.0)
Published:	2023-12-11
DOI:	10.32614/CRAN.package.simIDM
Author:	Alexandra Erdmann [aut, cre], Kaspar Rufibach [aut], Holger Löwe [aut], Daniel Sabanés Bové [aut], F. Hoffmann-La Roche AG [cph, fnd], University of Ulm [cph, fnd]
Maintainer:	Alexandra Erdmann <alexandra.erdmann at uni-ulm.de>
BugReports:	https://github.com/insightsengineering/simIDM/issues
License:	Apache License 2.0
URL:	https://github.com/insightsengineering/simIDM/
NeedsCompilation:	no
Language:	en-US
Materials:	NEWS
CRAN checks:	simIDM results

Documentation:

Reference manual:	simIDM.pdf
Vignettes:	Correlation between PFS and OS Piecewise Constant Hazards Calculations Getting Started Power and Type I Error Calculations

Downloads:

Package source:	simIDM_0.1.0.tar.gz
Windows binaries:	r-devel: simIDM_0.1.0.zip, r-release: simIDM_0.1.0.zip, r-oldrel: simIDM_0.1.0.zip
macOS binaries:	r-release (arm64): simIDM_0.1.0.tgz, r-oldrel (arm64): simIDM_0.1.0.tgz, r-release (x86_64): simIDM_0.1.0.tgz, r-oldrel (x86_64): simIDM_0.1.0.tgz
Old sources:	simIDM archive

Linking:

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