simFastBOIN: Fast Simulation of Bayesian Optimal Interval Designs for Phase I Trials

Design and evaluate phase I dose-finding trials that use the Bayesian optimal interval (BOIN) design of Liu and Yuan (2015) <doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision boundaries, to simulate trials, to estimate the dose-toxicity curve under a monotonicity constraint and to select the maximum tolerated dose. The simulation engine is written in C++ and draws one random variate per patient in enrollment order, which reproduces the reference implementation in the 'BOIN' package trial by trial for a given seed. The traditional 3+3 design is provided as a comparator, with operating characteristics obtained in closed form rather than by simulation.

Version:	2.0.0
Depends:	R (≥ 3.5.0)
Imports:	Rcpp (≥ 1.0.0), stats, utils
LinkingTo:	Rcpp
Suggests:	BOIN, ggplot2 (≥ 3.4.0), Iso, knitr, rmarkdown, spelling, testthat (≥ 3.0.0)
Published:	2026-09-18
DOI:	10.32614/CRAN.package.simFastBOIN
Author:	Gosuke Homma [aut, cre]
Maintainer:	Gosuke Homma <my.name.is.gosuke at gmail.com>
BugReports:	https://github.com/gosukehommaEX/simFastBOIN/issues
License:	MIT + file LICENSE
URL:	https://github.com/gosukehommaEX/simFastBOIN
NeedsCompilation:	yes
Language:	en-US
Materials:	README, NEWS
CRAN checks:	simFastBOIN results

Documentation:

Reference manual:	simFastBOIN.html , simFastBOIN.pdf
Vignettes:	Getting started with simFastBOIN (source, R code)

Downloads:

Package source:	simFastBOIN_2.0.0.tar.gz
Windows binaries:	r-devel: simFastBOIN_1.3.2.zip, r-release: simFastBOIN_1.3.2.zip, r-oldrel: simFastBOIN_2.0.0.zip
macOS binaries:	r-release (arm64): simFastBOIN_2.0.0.tgz, r-oldrel (arm64): simFastBOIN_2.0.0.tgz, r-release (x86_64): simFastBOIN_2.0.0.tgz, r-oldrel (x86_64): simFastBOIN_2.0.0.tgz
Old sources:	simFastBOIN archive

Linking:

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