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Implements the Backfill Bayesian Optimal Interval Design (BF-BOIN-ET), a novel clinical trial methodology for dose optimization that simultaneously consider both efficacy and toxicity outcome as described in (Takeda et al (2025) <doi:10.1002/pst.2470>). The package has been extended to include a seamless two-stage phase I/II trial design with backfill and joint efficacy and toxicity monitoring as described in (Takeda et al (2026) <doi:10.1002/pst.70092>).
| Version: | 1.0.0 |
| Imports: | Iso, copula, dplyr, tidyselect, magrittr, BOP2FE, boinet, BOIN |
| Published: | 2026-04-14 |
| DOI: | 10.32614/CRAN.package.bfboinet |
| Author: | Jing Zhu [cre, aut], Kentaro Takeda [aut], Yimer Belay Birlie [aut] |
| Maintainer: | Jing Zhu <zhujing716 at gmail.com> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Materials: | README, NEWS |
| CRAN checks: | bfboinet results |
| Reference manual: | bfboinet.html , bfboinet.pdf |
| Package source: | bfboinet_1.0.0.tar.gz |
| Windows binaries: | r-devel: bfboinet_1.0.0.zip, r-release: bfboinet_1.0.0.zip, r-oldrel: bfboinet_1.0.0.zip |
| macOS binaries: | r-release (arm64): bfboinet_1.0.0.tgz, r-oldrel (arm64): bfboinet_0.4.0.tgz, r-release (x86_64): bfboinet_1.0.0.tgz, r-oldrel (x86_64): bfboinet_1.0.0.tgz |
| Old sources: | bfboinet archive |
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