segregatr: Segregation Analysis for Variant Interpretation

An implementation of the full-likelihood Bayes factor (FLB) for evaluating segregation evidence in clinical medical genetics. The method was introduced by Thompson et al. (2003) <doi:10.1086/378100>. This implementation supports custom penetrance values and liability classes, and allows visualisations and robustness analysis as presented in Ratajska et al. (2023) <doi:10.1002/mgg3.2107>. See also the online app 'shinyseg', <https://chrcarrizosa.shinyapps.io/shinyseg>, which offers interactive segregation analysis with many additional features (Carrizosa et al. (2024) <doi:10.1093/bioinformatics/btae201>).

Version:	0.4.0
Depends:	pedtools (≥ 2.2.0), R (≥ 4.1.0)
Imports:	pedprobr
Suggests:	testthat
Published:	2024-06-28
DOI:	10.32614/CRAN.package.segregatr
Author:	Magnus Dehli Vigeland [aut, cre], Christian Carrizosa [aut]
Maintainer:	Magnus Dehli Vigeland <m.d.vigeland at medisin.uio.no>
BugReports:	https://github.com/magnusdv/segregatr/issues
License:	GPL-3
URL:	https://github.com/magnusdv/segregatr
NeedsCompilation:	no
Language:	en-GB
Citation:	segregatr citation info
Materials:	README NEWS
CRAN checks:	segregatr results

Documentation:

Reference manual:

segregatr.pdf

Downloads:

Package source:	segregatr_0.4.0.tar.gz
Windows binaries:	r-devel: segregatr_0.4.0.zip, r-release: segregatr_0.4.0.zip, r-oldrel: segregatr_0.4.0.zip
macOS binaries:	r-release (arm64): segregatr_0.4.0.tgz, r-oldrel (arm64): segregatr_0.4.0.tgz, r-release (x86_64): segregatr_0.4.0.tgz, r-oldrel (x86_64): segregatr_0.4.0.tgz
Old sources:	segregatr archive

Reverse dependencies:

Reverse imports:

pedsuite

Linking:

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