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Uses several Nonlinear Mixed effect (NONMEM) models (as NONMEM control files) to perform bootstrap model averaging and Monte Carlo Simulation for Model Based Bio-Equivalence (MBBE). Power is returned as the fraction of the simulations with successful bioequivalence (BE) test, for maximum concentration (Cmax), Area under the curve to the last observed value (AUClast) and Area under the curve extrapolate to infinity (AUCinf). See Hooker, A. (2020) Improved bioequivalence assessment through model-informed and model-based strategies <https://www.fda.gov/media/138035/download>.
Version: | 0.1.0 |
Imports: | dplyr, stringr, xml2, PKNCA, magrittr, nlme, emmeans, future, furrr (≥ 0.3.1), processx, tictoc, ggplot2, ps, jsonlite |
Suggests: | knitr, rmarkdown, testthat |
Published: | 2024-02-03 |
DOI: | 10.32614/CRAN.package.mbbe |
Author: | Mark Sale |
Maintainer: | Mark Sale <mark.sale at certara.com> |
BugReports: | https://github.com/certara/mbbe/issues |
License: | LGPL-3 |
URL: | https://github.com/certara/mbbe |
NeedsCompilation: | no |
Materials: | README |
CRAN checks: | mbbe results |
Reference manual: | mbbe.pdf |
Vignettes: |
Introduction Step-by-Step |
Package source: | mbbe_0.1.0.tar.gz |
Windows binaries: | r-devel: mbbe_0.1.0.zip, r-release: mbbe_0.1.0.zip, r-oldrel: mbbe_0.1.0.zip |
macOS binaries: | r-release (arm64): mbbe_0.1.0.tgz, r-oldrel (arm64): mbbe_0.1.0.tgz, r-release (x86_64): mbbe_0.1.0.tgz, r-oldrel (x86_64): mbbe_0.1.0.tgz |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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