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PKNCA: Perform Pharmacokinetic Non-Compartmental Analysis

Compute standard Non-Compartmental Analysis (NCA) parameters for typical pharmacokinetic analyses and summarize them.

Version: 0.11.0
Imports: checkmate, dplyr (≥ 0.5.0), digest, nlme, purrr, rlang, stats, tidyr, tibble, utils, lifecycle
Suggests: covr, cowplot, ggplot2, knitr, labeling, pander, pmxTools, rmarkdown, spelling, testthat (≥ 3.0.0), units, withr
Published: 2024-06-19
DOI: 10.32614/CRAN.package.PKNCA
Author: Bill Denney ORCID iD [aut, cre], Clare Buckeridge [aut], Sridhar Duvvuri [ctb]
Maintainer: Bill Denney <wdenney at humanpredictions.com>
BugReports: https://github.com/billdenney/pknca/issues
License: AGPL-3
URL: https://billdenney.github.io/pknca/, https://github.com/billdenney/pknca, http://billdenney.github.io/pknca/
NeedsCompilation: no
Language: en-US
Citation: PKNCA citation info
Materials: README NEWS
In views: MixedModels, Pharmacokinetics
CRAN checks: PKNCA results

Documentation:

Reference manual: PKNCA.pdf
Vignettes: Introduction to PKNCA and Usage Instructions (source, R code)
Computing NCA Parameters for Theophylline (source, R code)
Selection of Calculation Intervals (source, R code)
Sparse NCA Calculations (source, R code)
AUC Calculation with PKNCA (source, R code)
Half-life calculation with Tobit regression (source, R code)
Half-Life Calculation (source, R code)
Post-Processing (source, R code)
Unit Assignment and Conversion with PKNCA (source, R code)
Data Imputation (source, R code)
Superposition of Pharmacokinetic Data (source, R code)
Methods Used for Dose-Aware Concentration Interpolation/Extrapolation (source, R code)
Noncompartmental evaluation of time to steady-state (source, R code)
AUC integration methods (source, R code)
PKNCA Training Sessions (source, R code)
Options for Controlling PKNCA (source, R code)
PKNCA Validation (source, R code)
Writing PKNCA Parameter Functions (source, R code)

Downloads:

Package source: PKNCA_0.11.0.tar.gz
Windows binaries: r-devel: PKNCA_0.11.0.zip, r-release: PKNCA_0.11.0.zip, r-oldrel: PKNCA_0.11.0.zip
macOS binaries: r-release (arm64): PKNCA_0.11.0.tgz, r-oldrel (arm64): PKNCA_0.11.0.tgz, r-release (x86_64): PKNCA_0.11.0.tgz, r-oldrel (x86_64): PKNCA_0.11.0.tgz
Old sources: PKNCA archive

Reverse dependencies:

Reverse imports: mbbe, pmxTools, ruminate, ubiquity
Reverse suggests: babelmixr2

Linking:

Please use the canonical form https://CRAN.R-project.org/package=PKNCA to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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