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invitroTKstats: In Vitro Toxicokinetic Data Processing and Analysis Pipeline

A set of tools for processing and analyzing in vitro toxicokinetic measurements in a standardized and reproducible pipeline. The package was developed to perform frequentist and Bayesian estimation on a variety of in vitro toxicokinetic measurements including – but not limited to – chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The methods provided by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.

Version: 0.0.13
Depends: R (≥ 3.5.0)
Imports: runjags, parallel, readxl, coda, ggplot2, scales, stats4, Rdpack, methods, stats, utils, dplyr, rlang
Suggests: knitr, R.rsp, tidyverse, gridExtra, gridtext, flextable, rmarkdown, magrittr, stringr
Published: 2025-08-19
DOI: 10.32614/CRAN.package.invitroTKstats
Author: John Wambaugh ORCID iD [aut], Sarah E. Davidson-Fritz ORCID iD [aut, cre], Lindsay Knupp [ctb], Barbara A. Wetmore ORCID iD [ctb], Zhao Zhihui [ctb], Chantel Nicolas ORCID iD [ctb], Anna Kreutz ORCID iD [ctb], U.S. Federal Government [cph] (Copyright holder of this package)
Maintainer: Sarah E. Davidson-Fritz <davidsonfritz.sarah at epa.gov>
BugReports: https://github.com/USEPA/invitroTKstats/issues
License: MIT + file LICENSE
URL: https://github.com/USEPA/invitroTKstats
NeedsCompilation: no
Materials: README, NEWS
CRAN checks: invitroTKstats results

Documentation:

Reference manual: invitroTKstats.html , invitroTKstats.pdf
Vignettes: Appendix (source, R code)
Caco-2 (source, R code)
Clint (source, R code)
data_guide_and_LO (source, R code)
Fup RED (source, R code)
Fup UC (source, R code)
Plotting Functions (source, R code)

Downloads:

Package source: invitroTKstats_0.0.13.tar.gz
Windows binaries: r-devel: not available, r-release: invitroTKstats_0.0.13.zip, r-oldrel: invitroTKstats_0.0.13.zip
macOS binaries: r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): invitroTKstats_0.0.13.tgz, r-oldrel (x86_64): invitroTKstats_0.0.13.tgz

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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