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aNCA: (Pre-)Clinical NCA in a Dynamic Shiny App

An interactive 'shiny' application for performing non-compartmental analysis (NCA) on pre-clinical and clinical pharmacokinetic data. The package builds on 'PKNCA' for core estimators and provides interactive visualizations, CDISC outputs ('ADNCA', 'PP', 'ADPP') and configurable TLGs (tables, listings, and graphs). Typical use cases include exploratory analysis, validation, reporting or teaching/demonstration of NCA methods. Methods and core estimators are described in Denney, Duvvuri, and Buckeridge (2015) "Simple, Automatic Noncompartmental Analysis: The PKNCA R Package" <doi:10.1007/s10928-015-9432-2>.

Version: 0.1.0
Depends: R (≥ 4.1)
Imports: dplyr, formatters, flextable, ggplot2, magrittr, methods, officer, PKNCA (≥ 0.12.1), plotly, purrr, rlang, rlistings, scales, stats, stringr, tern, tidyr, units, utils
Suggests: arrow, covr, DT, ggh4x, glue, haven, htmltools, htmlwidgets, jsonlite, knitr, lintr (≥ 3.1.2), logger, markdown, mockery, nestcolor, openxlsx2, pak, reactable, reactable.extras, rmarkdown, sass, shiny, shinycssloaders, shinyjs, shinyjqui, shinytest2, shinyWidgets, stringi, testthat (≥ 3.0.0), tools, quarto, vdiffr, withr, yaml
Published: 2025-12-09
DOI: 10.32614/CRAN.package.aNCA (may not be active yet)
Author: Ercan Suekuer ORCID iD [aut], Gerardo Jose Rodriguez ORCID iD [aut], Pascal Baertschi ORCID iD [aut], Jana Spinner ORCID iD [aut], Mateusz Kolomanski ORCID iD [aut], Lucy Aspridis ORCID iD [aut], Valentin Legras [aut, cre], F. Hoffmann-La Roche AG [cph, fnd]
Maintainer: Valentin Legras <anca.pharmaverse at gmail.com>
BugReports: https://github.com/pharmaverse/aNCA/issues
License: Apache License (≥ 2)
URL: https://pharmaverse.github.io/aNCA/, https://github.com/pharmaverse/aNCA
NeedsCompilation: no
Language: en-US
Materials: README
CRAN checks: aNCA results

Documentation:

Reference manual: aNCA.html , aNCA.pdf
Vignettes: aNCA Shiny App User Guide (source)
Adding new TLGs to the package (source)
Contributing to aNCA (source)

Downloads:

Package source: aNCA_0.1.0.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries: r-release (arm64): aNCA_0.1.0.tgz, r-oldrel (arm64): aNCA_0.1.0.tgz, r-release (x86_64): aNCA_0.1.0.tgz, r-oldrel (x86_64): aNCA_0.1.0.tgz

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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