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This tool is extended from methods in Bio.SeqUtils.MeltingTemp of python. The melting temperature of nucleic acid sequences can be calculated in three method, the Wallace rule (Thein & Wallace (1986) <doi:10.1016/S0140-6736(86)90739-7>), empirical formulas based on G and C content (Marmur J. (1962) <doi:10.1016/S0022-2836(62)80066-7>, Schildkraut C. (2010) <doi:10.1002/bip.360030207>, Wetmur J G (1991) <doi:10.3109/10409239109114069>, Untergasser,A. (2012) <doi:10.1093/nar/gks596>, von Ahsen N (2001) <doi:10.1093/clinchem/47.11.1956>) and nearest neighbor thermodynamics (Breslauer K J (1986) <doi:10.1073/pnas.83.11.3746>, Sugimoto N (1996) <doi:10.1093/nar/24.22.4501>, Allawi H (1998) <doi:10.1093/nar/26.11.2694>, SantaLucia J (2004) <doi:10.1146/annurev.biophys.32.110601.141800>, Freier S (1986) <doi:10.1073/pnas.83.24.9373>, Xia T (1998) <doi:10.1021/bi9809425>, Chen JL (2012) <doi:10.1021/bi3002709>, Bommarito S (2000) <doi:10.1093/nar/28.9.1929>, Turner D H (2010) <doi:10.1093/nar/gkp892>, Sugimoto N (1995) <doi:10.1016/S0048-9697(98)00088-6>, Allawi H T (1997) <doi:10.1021/bi962590c>, Santalucia N (2005) <doi:10.1093/nar/gki918>), and it can also be corrected with salt ions and chemical compound (SantaLucia J (1996) <doi:10.1021/bi951907q>, SantaLucia J(1998) <doi:10.1073/pnas.95.4.1460>, Owczarzy R (2004) <doi:10.1021/bi034621r>, Owczarzy R (2008) <doi:10.1021/bi702363u>).
| Version: | 1.0.3 |
| Depends: | R (≥ 2.10) |
| Published: | 2022-02-21 |
| Author: | Junhui Li |
| Maintainer: | Junhui Li <junhuili at cau.edu.cn> |
| BugReports: | https://github.com/JunhuiLi1017/TmCalculator/issues |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | TmCalculator results |
| Reference manual: | TmCalculator.pdf |
| Package source: | TmCalculator_1.0.3.tar.gz |
| Windows binaries: | r-devel: TmCalculator_1.0.3.zip, r-release: TmCalculator_1.0.3.zip, r-oldrel: TmCalculator_1.0.3.zip |
| macOS binaries: | r-release (arm64): TmCalculator_1.0.3.tgz, r-oldrel (arm64): TmCalculator_1.0.3.tgz, r-release (x86_64): TmCalculator_1.0.3.tgz, r-oldrel (x86_64): TmCalculator_1.0.3.tgz |
| Old sources: | TmCalculator archive |
| Reverse imports: | ProbeDeveloper |
| Reverse suggests: | disprose |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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