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Helps a clinical trial team discuss the clinical goals of a well-defined biomarker with a diagnostic, staging, prognostic, or predictive purpose. From this discussion will come a statistical plan for a (non-randomized) validation trial. Both prospective and retrospective trials are supported. In a specific focused discussion, investigators should determine the range of "discomfort" for the NNT, number needed to treat. The meaning of the discomfort range, [NNTlower, NNTupper], is that within this range most physicians would feel discomfort either in treating or withholding treatment. A pair of NNT values bracketing that range, NNTpos and NNTneg, become the targets of the study's design. If the trial can demonstrate that a positive biomarker test yields an NNT less than NNTlower, and that a negative biomarker test yields an NNT less than NNTlower, then the biomarker may be useful for patients. A highlight of the package is visualization of a "contra-Bayes" theorem, which produces criteria for retrospective case-controls studies.
| Version: | 0.29.11 |
| Imports: | shiny, xtable, stringr, magrittr, mvbutils |
| Suggests: | testthat (≥ 0.8.1), knitr (≥ 1.6), rmarkdown, ggplot2, plyr |
| Published: | 2015-08-21 |
| Author: | Roger Day |
| Maintainer: | Roger Day <day01 at pitt.edu> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| CRAN checks: | NNTbiomarker results |
| Reference manual: | NNTbiomarker.pdf |
| Vignettes: |
The biomarker crisis Using the NNTbiomarker package The debugTools component |
| Package source: | NNTbiomarker_0.29.11.tar.gz |
| Windows binaries: | r-devel: NNTbiomarker_0.29.11.zip, r-release: NNTbiomarker_0.29.11.zip, r-oldrel: NNTbiomarker_0.29.11.zip |
| macOS binaries: | r-release (arm64): NNTbiomarker_0.29.11.tgz, r-oldrel (arm64): NNTbiomarker_0.29.11.tgz, r-release (x86_64): NNTbiomarker_0.29.11.tgz, r-oldrel (x86_64): NNTbiomarker_0.29.11.tgz |
| Old sources: | NNTbiomarker archive |
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