LTFHPlus: Implementation of LT-FH++

Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <doi:10.1016/j.ajhg.2022.01.009> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <doi:10.1038/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.

Version:	2.1.2
Imports:	batchmeans, dplyr, future.apply, future, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr
LinkingTo:	Rcpp
Suggests:	MASS, knitr, rmarkdown, testthat
Published:	2024-11-22
DOI:	10.32614/CRAN.package.LTFHPlus
Author:	Emil Michael Pedersen [aut, cre], Florian Privé [aut, ths], Bjarni Jóhann Vilhjálmsson [ths], Esben Agerbo [ths], Jette Steinbach [aut], Lucas Rasmussen [ctb]
Maintainer:	Emil Michael Pedersen <emp at ph.au.dk>
BugReports:	https://github.com/EmilMiP/LTFHPlus/issues
License:	GPL-3
URL:	https://github.com/EmilMiP/LTFHPlus
NeedsCompilation:	yes
Language:	en-GB
Materials:	README NEWS
CRAN checks:	LTFHPlus results

Documentation:

Reference manual:

LTFHPlus.pdf

Downloads:

Package source:	LTFHPlus_2.1.2.tar.gz
Windows binaries:	r-devel: LTFHPlus_2.1.2.zip, r-release: LTFHPlus_2.1.2.zip, r-oldrel: LTFHPlus_2.1.2.zip
macOS binaries:	r-release (arm64): LTFHPlus_2.1.2.tgz, r-oldrel (arm64): LTFHPlus_2.1.2.tgz, r-release (x86_64): LTFHPlus_2.1.2.tgz, r-oldrel (x86_64): LTFHPlus_2.1.2.tgz
Old sources:	LTFHPlus archive

Linking:

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