LTFGRS: Implementation of Several Phenotype-Based Family Genetic Risk Scores

Implementation of several phenotype-based family genetic risk scores with unified input data and data preparation functions to help facilitate the required data preparation and management. The implemented family genetic risk scores are the extended liability threshold model conditional on family history (LT-FH++) from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>, Pearson-Aitken Family Genetic Risk Scores (PA-FGRS) from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>, and family genetic risk score by Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.

Version:	1.0.0
Imports:	batchmeans, dplyr, future.apply, future, lubridate, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr
LinkingTo:	Rcpp
Suggests:	knitr, rmarkdown, testthat (≥ 3.0.0), MASS
Published:	2025-07-07
DOI:	10.32614/CRAN.package.LTFGRS
Author:	Emil Michael Pedersen [aut, cre], Jette Steinbach [aut], Lucas Rasmussen [ctb], Morten Dybdahl Krebs [aut]
Maintainer:	Emil Michael Pedersen <emp at ph.au.dk>
BugReports:	https://github.com/EmilMiP/LTFGRS/issues
License:	GPL (≥ 3)
URL:	https://emilmip.github.io/LTFGRS/
NeedsCompilation:	yes
Language:	en-GB
Materials:	README, NEWS
CRAN checks:	LTFGRS results

Documentation:

Reference manual:	LTFGRS.html , LTFGRS.pdf
Vignettes:	LTFGRS Workflow: Prepare Genetic Liability for Prediction (source, R code)

Downloads:

Package source:	LTFGRS_1.0.0.tar.gz
Windows binaries:	r-devel: LTFGRS_1.0.0.zip, r-release: LTFGRS_1.0.0.zip, r-oldrel: LTFGRS_1.0.0.zip
macOS binaries:	r-release (arm64): LTFGRS_1.0.0.tgz, r-oldrel (arm64): LTFGRS_1.0.0.tgz, r-release (x86_64): LTFGRS_1.0.0.tgz, r-oldrel (x86_64): LTFGRS_1.0.0.tgz

Linking:

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