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Implementation of several phenotype-based family genetic risk scores with unified input data and data preparation functions to help facilitate the required data preparation and management. The implemented family genetic risk scores are the extended liability threshold model conditional on family history (LT-FH++) from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>, Pearson-Aitken Family Genetic Risk Scores (PA-FGRS) from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>, and family genetic risk score by Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.
Version: | 1.0.0 |
Imports: | batchmeans, dplyr, future.apply, future, lubridate, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr |
LinkingTo: | Rcpp |
Suggests: | knitr, rmarkdown, testthat (≥ 3.0.0), MASS |
Published: | 2025-07-07 |
DOI: | 10.32614/CRAN.package.LTFGRS |
Author: | Emil Michael Pedersen [aut, cre], Jette Steinbach [aut], Lucas Rasmussen [ctb], Morten Dybdahl Krebs [aut] |
Maintainer: | Emil Michael Pedersen <emp at ph.au.dk> |
BugReports: | https://github.com/EmilMiP/LTFGRS/issues |
License: | GPL (≥ 3) |
URL: | https://emilmip.github.io/LTFGRS/ |
NeedsCompilation: | yes |
Language: | en-GB |
Materials: | README NEWS |
CRAN checks: | LTFGRS results [issues need fixing before 2025-07-21] |
Reference manual: | LTFGRS.pdf |
Vignettes: |
LTFGRS Workflow: Prepare Genetic Liability for Prediction (source, R code) |
Package source: | LTFGRS_1.0.0.tar.gz |
Windows binaries: | r-devel: not available, r-release: not available, r-oldrel: not available |
macOS binaries: | r-release (arm64): LTFGRS_1.0.0.tgz, r-oldrel (arm64): LTFGRS_1.0.0.tgz, r-release (x86_64): LTFGRS_1.0.0.tgz, r-oldrel (x86_64): LTFGRS_1.0.0.tgz |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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