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bioIOT: Inverse Optimal Transport for Single-Cell Trajectory Analysis

Semi-relaxed inverse optimal transport (IOT) for single-cell state-transition and pseudotime analysis: a self-contained R solver (Anderson-accelerated soft Sinkhorn with exact implicit gradients), feature-weight fitting with a two-stage bias-corrected refit and multi-restart, state transition matrices, random-walk pseudotime, 'ggplot2' visualisation, soft-gated 'Seurat' and 'SingleCellExperiment' interfaces, reproducible simulated demo data, and bulk-cohort pathway scoring utilities.

Version: 0.2.2
Depends: R (≥ 4.0.0)
Imports: utils, ggplot2
Suggests: testthat (≥ 3.0.0), knitr, rmarkdown, SingleCellExperiment, Seurat, SummarizedExperiment, S4Vectors
Published: 2026-09-24
DOI: 10.32614/CRAN.package.bioIOT (may not be active yet)
Author: Han Dong [aut, cre] (Nickname: XTSgreen)
Maintainer: Han Dong <dh411424 at 163.com>
BugReports: https://github.com/XTSgreen/bioIOT-R/issues
License: MIT + file LICENSE
URL: https://github.com/XTSgreen/bioIOT-R
NeedsCompilation: no
Citation: bioIOT citation info
Materials: README, NEWS
CRAN checks: bioIOT results

Documentation:

Reference manual: bioIOT.html , bioIOT.pdf
Vignettes: bioIOT quickstart (source, R code)

Downloads:

Package source: bioIOT_0.2.2.tar.gz
Windows binaries: r-devel: not available, r-release: bioIOT_0.2.2.zip, r-oldrel: bioIOT_0.2.2.zip
macOS binaries: r-release (arm64): bioIOT_0.2.2.tgz, r-oldrel (arm64): bioIOT_0.2.2.tgz, r-release (x86_64): bioIOT_0.2.2.tgz, r-oldrel (x86_64): bioIOT_0.2.2.tgz

Linking:

Please use the canonical form https://CRAN.R-project.org/package=bioIOT to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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