OneArm2stage: Phase II Single-Arm Two-Stage Designs with Time-to-Event Outcomes

Two-stage design for single-arm phase II trials with time-to-event endpoints (e.g., clinical trials on immunotherapies among cancer patients) can be calculated using this package. Two notable advantages of the package: 1) It provides flexible choices from three design methods (optimal, minmax, and admissible), and 2) the power of the design is more accurately calculated using the exact variance in the one-sample log-rank test. The package can be used for 1) planning the sample sizes and other design parameters, and 2) conducting the interim and final analyses for the Go/No-go decisions. More details about the design method can be found in: Wu, J, Chen L, Wei J, Weiss H, Chauhan A. (2020). <doi:10.1002/pst.1983>.

Version:	1.2.1
Depends:	R (≥ 3.5.0)
Imports:	survival, utils, flexsurv, IPDfromKM
Suggests:	knitr, rmarkdown, testthat (≥ 3.0.0)
Published:	2023-10-09
Author:	Xiaomeng Yuan [aut, cre], Haitao Pan [aut], Jianrong Wu [aut]
Maintainer:	Xiaomeng Yuan <xiaomeng.yuan at stjude.org>
License:	GPL (≥ 3)
NeedsCompilation:	no
Materials:	NEWS
CRAN checks:	OneArm2stage results

Documentation:

Reference manual:	OneArm2stage.pdf
Vignettes:	OneArm2stage

Downloads:

Package source:	OneArm2stage_1.2.1.tar.gz
Windows binaries:	r-devel: OneArm2stage_1.2.1.zip, r-release: OneArm2stage_1.2.1.zip, r-oldrel: OneArm2stage_1.2.1.zip
macOS binaries:	r-release (arm64): OneArm2stage_1.2.1.tgz, r-oldrel (arm64): OneArm2stage_1.2.1.tgz, r-release (x86_64): OneArm2stage_1.2.1.tgz, r-oldrel (x86_64): OneArm2stage_1.2.1.tgz
Old sources:	OneArm2stage archive

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