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## Authentication complete.## No. of Views 525112
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## No. of Comments 5329## <?xml version="1.0" encoding="utf-8"?>
## <transcript>
## <text start="6.614" dur="1.549">Every four seconds,</text>
## <text start="8.163" dur="1.534">someone is diagnosed with</text>
## <text start="9.697" dur="1.885">Alzheimer&#39;s disease.</text>
## <text start="11.582" dur="2.172">It&#39;s the most common cause of dementia,</text>
## <text start="13.754" dur="2.859">affecting over 40 million people worldwide,</text>
## <text start="16.613" dur="2.52">and yet finding a cure is something that still</text>
## <text start="19.133" dur="2.482">eludes researchers today.</text>
## <text start="21.615" dur="3.273">Dr. Alois Alzheimer, a German psychiatrist,</text>
## <text start="24.888" dur="3.047">first described the symptoms in 1901</text>
## <text start="27.935" dur="2.46">when he noticed that a particular hospital patient</text>
## <text start="30.395" dur="1.917">had some peculiar problems,</text>
## <text start="32.312" dur="1.803">including difficulty sleeping,</text>
## <text start="34.115" dur="3.37">disturbed memory, drastic mood changes,</text>
## <text start="37.485" dur="2.166">and increasing confusion.</text>
## <text start="39.651" dur="1.877">When the patient passed away,</text>
## <text start="41.528" dur="2.211">Alzheimer was able to do an autopsy</text>
## <text start="43.739" dur="2.04">and test his idea that perhaps</text>
## <text start="45.779" dur="2.421">her symptoms were caused by irregularities</text>
## <text start="48.2" dur="1.963">in the brain&#39;s structure.</text>
## <text start="50.163" dur="1.951">What he found beneath the microscope</text>
## <text start="52.114" dur="2.473">were visible differences in brain tissue</text>
## <text start="54.587" dur="2.194">in the form of misfolded proteins</text>
## <text start="56.781" dur="1.334">called plaques,</text>
## <text start="58.115" dur="2.433">and neurofibrillary tangles.</text>
## <text start="60.548" dur="2.378">Those plaques and tangles work together</text>
## <text start="62.926" dur="2.419">to break down the brain&#39;s structure.</text>
## <text start="65.345" dur="1.792">Plaques arise when another protein</text>
## <text start="67.137" dur="2.643">in the fatty membrane surrounding nerve cells</text>
## <text start="69.78" dur="2.697">gets sliced up by a particular enzyme,</text>
## <text start="72.477" dur="2.585">resulting in beta-amyloid proteins,</text>
## <text start="75.062" dur="1.799">which are sticky and have a tendency</text>
## <text start="76.861" dur="1.587">to clump together.</text>
## <text start="78.448" dur="1.952">That clumping is what forms the things</text>
## <text start="80.4" dur="2.131">we know as plaques.</text>
## <text start="82.531" dur="1.793">These clumps block signaling</text>
## <text start="84.324" dur="1.502">and, therefore, communication</text>
## <text start="85.826" dur="2.336">between cells, and also seem to trigger</text>
## <text start="88.162" dur="2.536">immune reactions that cause the destruction</text>
## <text start="90.698" dur="2.134">of disabled nerve cells.</text>
## <text start="92.832" dur="2.782">In Alzheimer&#39;s disease, neurofibrillary tangles</text>
## <text start="95.614" dur="3.085">are built from a protein known as tau.</text>
## <text start="98.699" dur="2.89">The brain&#39;s nerve cells contain a network of tubes</text>
## <text start="101.589" dur="2.024">that act like a highway for food molecules</text>
## <text start="103.613" dur="1.563">among other things.</text>
## <text start="105.176" dur="2.543">Usually, the tau protein ensures that these tubes</text>
## <text start="107.719" dur="2.256">are straight, allowing molecules</text>
## <text start="109.975" dur="1.917">to pass through freely.</text>
## <text start="111.892" dur="1.709">But in Alzheimer&#39;s disease,</text>
## <text start="113.601" dur="3.463">the protein collapses into twisted strands or tangles,</text>
## <text start="117.064" dur="1.832">making the tubes disintegrate,</text>
## <text start="118.896" dur="2.505">obstructing nutrients from reaching the nerve cell</text>
## <text start="121.401" dur="2.628">and leading to cell death.</text>
## <text start="124.029" dur="2.336">The destructive pairing of plaques and tangles</text>
## <text start="126.365" dur="2.332">starts in a region called the hippocampus,</text>
## <text start="128.697" dur="2.419">which is responsible for forming memories.</text>
## <text start="131.116" dur="1.713">That&#39;s why short-term memory loss</text>
## <text start="132.829" dur="2.702">is usually the first symptom of Alzheimer&#39;s.</text>
## <text start="135.531" dur="1.884">The proteins then progressively invade</text>
## <text start="137.415" dur="1.616">other parts of the brain,</text>
## <text start="139.031" dur="1.834">creating unique changes that signal</text>
## <text start="140.865" dur="2.416">various stages of the disease.</text>
## <text start="143.281" dur="1.235">At the front of the brain,</text>
## <text start="144.516" dur="3.536">the proteins destroy the ability to process logical thoughts.</text>
## <text start="148.052" dur="3.168">Next, they shift to the region that controls emotions,</text>
## <text start="151.22" dur="2.337">resulting in erratic mood changes.</text>
## <text start="153.557" dur="1.224">At the top of the brain,</text>
## <text start="154.781" dur="2.364">they cause paranoia and hallucinations,</text>
## <text start="157.145" dur="2.053">and once they reach the brain&#39;s rear,</text>
## <text start="159.198" dur="1.999">the plaques and tangles work together</text>
## <text start="161.197" dur="2.418">to erase the mind&#39;s deepest memories.</text>
## <text start="163.615" dur="1.621">Eventually the control centers governing</text>
## <text start="165.236" dur="2.794">heart rate and breathing are overpowered as well</text>
## <text start="168.03" dur="1.796">resulting in death.</text>
## <text start="169.826" dur="2.039">The immensely destructive nature of this disease</text>
## <text start="171.865" dur="2.999">has inspired many researchers to look for a cure</text>
## <text start="174.864" dur="3.752">but currently they&#39;re focused on slowing its progression.</text>
## <text start="178.616" dur="1.387">One temporary treatment</text>
## <text start="180.003" dur="2.627">helps reduce the break down of acetylcholine,</text>
## <text start="182.63" dur="2.653">an important chemical messenger in the brain</text>
## <text start="185.283" dur="2.519">which is decreased in Alzheimer&#39;s patients</text>
## <text start="187.802" dur="3.063">due to the death of the nerve cells that make it.</text>
## <text start="190.865" dur="2.316">Another possible solution is a vaccine</text>
## <text start="193.181" dur="2.461">that trains the body&#39;s immune system to attack</text>
## <text start="195.642" dur="3.587">beta-amyloid plaques before they can form clumps.</text>
## <text start="199.229" dur="2.801">But we still need to find an actual cure.</text>
## <text start="202.03" dur="1.75">Alzheimer&#39;s disease was discovered</text>
## <text start="203.78" dur="1.669">more than a century ago,</text>
## <text start="205.449" dur="2.664">and yet still it is not well understood.</text>
## <text start="208.113" dur="1.667">Perhaps one day we&#39;ll grasp</text>
## <text start="209.78" dur="2.916">the exact mechanisms at work behind this threat</text>
## <text start="212.696" dur="2.214">and a solution will be unearthed.</text>
## </transcript>
## ## publishedAt channelId title
## 1 2016-09-06T11:20:20.000Z UC6CZwQv8cbZco3wOwtp7W2g See How Obama Ignored Xi Jinping & Welcomed PM Modi At G20 Summit !
## 2 2016-09-05T06:01:17.000Z UC6RJ7-PaXg6TIH2BzZfTV7w PM Modi Meets Barack Obama at G20 Summit 2016
## 3 2008-03-24T16:31:53.000Z UC4o-h3-3GhrmHB6ytgO3oIQ Top 20 Obama Pastor Comments You Never Saw
## 4 2016-09-03T06:43:38.000Z UC5aeU5hk31cLzq_sAExLVWg LIVE: Obama arrives in China for G20 summit
## 5 2016-09-20T01:30:42.000Z UCmWHDwXFvdKc8OVBbb2dMZg Buy Lot of 20 Obama, 44th U.S. President, 56th Presidential Inauguration coins!
## 6 2016-09-03T06:57:05.000Z UCgrNz-aDmcr2uuto8_DL2jg US President Obama arrives in Hangzhou for G20 Summit## authorDisplayName authorProfileImageUrl authorChannelUrl
## 1 Tony Rx https://lh5.googleusercontent.com/-OL_t2gRZ8RI/AAAAAAAAAAI/AAAAAAAAACg/tXnqTDNYXec/photo.jpg?sz=50 http://www.youtube.com/channel/UCqKvEBPMtbmh020d56WrQXQ
## 2 Kevin Manning https://lh3.googleusercontent.com/-XdUIqdMkCWA/AAAAAAAAAAI/AAAAAAAAAAA/4252rscbv5M/photo.jpg?sz=50 http://www.youtube.com/channel/UCEF-WytcLvgijQIklAbteUw
## 3 Kevin Manning https://lh3.googleusercontent.com/-XdUIqdMkCWA/AAAAAAAAAAI/AAAAAAAAAAA/4252rscbv5M/photo.jpg?sz=50 http://www.youtube.com/channel/UCEF-WytcLvgijQIklAbteUw
## 4 TheDrunkenRocketMan https://lh3.googleusercontent.com/-XdUIqdMkCWA/AAAAAAAAAAI/AAAAAAAAAAA/4252rscbv5M/photo.jpg?sz=50 http://www.youtube.com/channel/UCvTypSrsihX3fr2zCZivmwA
## 5 pangratata https://lh3.googleusercontent.com/-XdUIqdMkCWA/AAAAAAAAAAI/AAAAAAAAAAA/4252rscbv5M/photo.jpg?sz=50 http://www.youtube.com/channel/UCETB8ILZueyFMCFWMF0p3Yg
## 6 pangratata https://lh3.googleusercontent.com/-XdUIqdMkCWA/AAAAAAAAAAI/AAAAAAAAAAA/4252rscbv5M/photo.jpg?sz=50 http://www.youtube.com/channel/UCETB8ILZueyFMCFWMF0p3Yg
a <- list_channel_resources(filter = c(channel_id = "UCT5Cx1l4IS3wHkJXNyuj4TA"), part="contentDetails")
# Uploaded playlists:
playlist_id <- a$items[[1]]$contentDetails$relatedPlaylists$uploads
# Get videos on the playlist
vids <- get_playlist_items(filter= c(playlist_id=playlist_id))
# Video ids
vid_ids <- as.vector(vids$contentDetails.videoId)
# Function to scrape stats for all vids
get_all_stats <- function(id) {
get_stats(id)
}
# Get stats and convert results to data frame
res <- lapply(vid_ids, get_all_stats)
res_df <- do.call(rbind, lapply(res, data.frame))
head(res_df)## id viewCount likeCount dislikeCount favoriteCount commentCount
## 1 91gZ4taDiDE 906 4 1 0 0
## 2 bHPCvSqTxn4 706 0 0 0 0
## 3 h2UPH87kjhc 458 1 0 0 0
## 4 E2VtxjljZCE 391 0 0 0 0
## 5 5Ajfk620fA0 175000 5 0 0 0
## 6 PdI3HjulcA4 575 3 2 0 3These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.