tcplfit2: A Concentration-Response Modeling Utility

The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the tcpl R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.

Version:	0.1.7
Depends:	R (≥ 3.5.0)
Imports:	stats, methods, numDeriv, RColorBrewer, stringr, reshape2, ggplot2
Suggests:	knitr, rmarkdown, stringi, DT, data.table, tcpl, prettydoc, testthat (≥ 3.0.0), here, htmlTable, tidyr, dplyr, gridExtra, rmdformats
Published:	2024-09-23
DOI:	10.32614/CRAN.package.tcplfit2
Author:	Thomas Sheffield [aut], Richard S Judson [ctb], Jason Brown [cre], Sarah E. Davidson [ctb], Zhihui Zhao [ctb], Madison Feshuk [ctb], Katie Paul Friedman [ctb]
Maintainer:	Jason Brown <brown.jason at epa.gov>
BugReports:	https://github.com/USEPA/CompTox-ToxCast-tcplFit2/issues
License:	MIT + file LICENSE
URL:	https://github.com/USEPA/CompTox-ToxCast-tcplFit2
NeedsCompilation:	no
Materials:	README NEWS
CRAN checks:	tcplfit2 results

Documentation:

Reference manual:	tcplfit2.pdf
Vignettes:	1. Introduction to tcplfit2 (source, R code)

Downloads:

Package source:	tcplfit2_0.1.7.tar.gz
Windows binaries:	r-devel: tcplfit2_0.1.7.zip, r-release: tcplfit2_0.1.7.zip, r-oldrel: tcplfit2_0.1.7.zip
macOS binaries:	r-release (arm64): tcplfit2_0.1.7.tgz, r-oldrel (arm64): tcplfit2_0.1.7.tgz, r-release (x86_64): tcplfit2_0.1.7.tgz, r-oldrel (x86_64): tcplfit2_0.1.7.tgz
Old sources:	tcplfit2 archive

Reverse dependencies:

Reverse imports:

tcpl

Linking:

Please use the canonical form https://CRAN.R-project.org/package=tcplfit2 to link to this page.