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replicateBE: Average Bioequivalence with Expanding Limits (ABEL)

Performs comparative bioavailability calculations for Average Bioequivalence with Expanding Limits (ABEL). Implemented are 'Method A' / 'Method B' and the detection of outliers. If the design allows, assessment of the empiric Type I Error and iteratively adjusting alpha to control the consumer risk. Average Bioequivalence - optionally with a tighter (narrow therapeutic index drugs) or wider acceptance range (South Africa: Cmax) - is implemented as well.

Version: 1.1.3
Depends: R (≥ 3.5.0)
Imports: readxl (≥ 1.0.0), PowerTOST (≥ 1.5.3), lmerTest, nlme, pbkrtest, graphics, grDevices
Suggests: knitr, rmarkdown, testthat, devtools
Published: 2022-05-02
DOI: 10.32614/CRAN.package.replicateBE
Author: Helmut Schütz ORCID iD [aut, cre], Michael Tomashevskiy [ctb], Detlew Labes ORCID iD [ctb]
Maintainer: Helmut Schütz <helmut.schuetz at bebac.at>
BugReports: https://github.com/Helmut01/replicateBE/issues
License: GPL (≥ 3)
URL: https://github.com/Helmut01/replicateBE
NeedsCompilation: no
Materials: README NEWS
In views: ClinicalTrials
CRAN checks: replicateBE results

Documentation:

Reference manual: replicateBE.pdf
Vignettes: replicateBE

Downloads:

Package source: replicateBE_1.1.3.tar.gz
Windows binaries: r-devel: replicateBE_1.1.3.zip, r-release: replicateBE_1.1.3.zip, r-oldrel: replicateBE_1.1.3.zip
macOS binaries: r-release (arm64): replicateBE_1.1.3.tgz, r-oldrel (arm64): replicateBE_1.1.3.tgz, r-release (x86_64): replicateBE_1.1.3.tgz, r-oldrel (x86_64): replicateBE_1.1.3.tgz
Old sources: replicateBE archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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