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pmxNODE: Application of NODEs in 'Monolix', 'NONMEM', and 'nlmixr2'

An easy-to-use tool for implementing Neural Ordinary Differential Equations (NODEs) in pharmacometric software such as 'Monolix', 'NONMEM', and 'nlmixr2', see Bräm et al. (2024) <doi:10.1007/s10928-023-09886-4> and Bräm et al. (2025) <doi:10.1002/psp4.13265>. The main functionality is to automatically generate structural model code describing computations within a neural network. Additionally, parameters and software settings can be initialized automatically. For using these additional functionalities with 'Monolix', 'pmxNODE' interfaces with 'MonolixSuite' via the 'lixoftConnectors' package. The 'lixoftConnectors' package is distributed with 'MonolixSuite' (<https://monolixsuite.slp-software.com/r-functions/2024R1/package-lixoftconnectors>) and is not available from public repositories.

Version: 0.1.0
Imports: tidyr, ggplot2, checkmate
Suggests: rxode2, nlmixr2, lixoftConnectors, withr, testthat (≥ 3.0.0), knitr, rmarkdown
Published: 2025-11-26
DOI: 10.32614/CRAN.package.pmxNODE (may not be active yet)
Author: Dominic Bräm ORCID iD [aut, cre], Bernhard Steiert [ctb], Gilbert Koch [ctb], Matthew Fidler ORCID iD [ctb]
Maintainer: Dominic Bräm <domi.braem at hotmail.com>
BugReports: https://github.com/braemd/pmxNODE/issues
License: GPL (≥ 3)
NeedsCompilation: no
Citation: pmxNODE citation info
Materials: README
CRAN checks: pmxNODE results

Documentation:

Reference manual: pmxNODE.html , pmxNODE.pdf
Vignettes: pmxNODE in Monolix (source, R code)
pmxNODE in NONMEM (source, R code)

Downloads:

Package source: pmxNODE_0.1.0.tar.gz
Windows binaries: r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries: r-release (arm64): pmxNODE_0.1.0.tgz, r-oldrel (arm64): pmxNODE_0.1.0.tgz, r-release (x86_64): pmxNODE_0.1.0.tgz, r-oldrel (x86_64): pmxNODE_0.1.0.tgz

Linking:

Please use the canonical form https://CRAN.R-project.org/package=pmxNODE to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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