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Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.
| Version: | 0.1.0 |
| Depends: | R (≥ 2.10) |
| Imports: | data.table, dplyr, stats, rlang, mvtnorm, fs, arrow, checkmate, cli, gdata, glue, purrr, tibble, vroom |
| Suggests: | knitr, rmarkdown, testthat (≥ 3.0.0) |
| Published: | 2025-10-28 |
| DOI: | 10.32614/CRAN.package.pleioh2g (may not be active yet) |
| Author: | Yujie Zhao [aut, cre] |
| Maintainer: | Yujie Zhao <yujiezhao at hsph.harvard.edu> |
| License: | GPL-3 |
| NeedsCompilation: | no |
| Language: | en-US |
| CRAN checks: | pleioh2g results |
| Reference manual: | pleioh2g.html , pleioh2g.pdf |
| Vignettes: |
pleioh2g-tutorial (source, R code) |
| Package source: | pleioh2g_0.1.0.tar.gz |
| Windows binaries: | r-devel: not available, r-release: pleioh2g_0.1.0.zip, r-oldrel: not available |
| macOS binaries: | r-release (arm64): pleioh2g_0.1.0.tgz, r-oldrel (arm64): pleioh2g_0.1.0.tgz, r-release (x86_64): pleioh2g_0.1.0.tgz, r-oldrel (x86_64): pleioh2g_0.1.0.tgz |
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These binaries (installable software) and packages are in development.
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