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Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.
| Version: | 1.0.9 |
| Depends: | R (≥ 3.0.0), coda, boot, rjags, mvtnorm, ggplot2 |
| Imports: | arrayhelpers |
| Suggests: | BiocParallel |
| Published: | 2020-03-11 |
| DOI: | 10.32614/CRAN.package.phase1RMD |
| Author: | Jun Yin, Yu Du, Sumithra Mandrekar |
| Maintainer: | Jun Yin <vivien.jyin at gmail.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | phase1RMD results |
| Reference manual: | phase1RMD.pdf |
| Package source: | phase1RMD_1.0.9.tar.gz |
| Windows binaries: | r-devel: phase1RMD_1.0.9.zip, r-release: phase1RMD_1.0.9.zip, r-oldrel: phase1RMD_1.0.9.zip |
| macOS binaries: | r-release (arm64): phase1RMD_1.0.9.tgz, r-oldrel (arm64): phase1RMD_1.0.9.tgz, r-release (x86_64): phase1RMD_1.0.9.tgz, r-oldrel (x86_64): phase1RMD_1.0.9.tgz |
| Old sources: | phase1RMD archive |
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