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| name | description |
|---|---|
| PK_1cmt | One compartment PK model with linear clearance |
| PK_1cmt_des | One compartment PK model with linear clearance using differential equations |
| PK_2cmt | Two compartment PK model with linear clearance |
| PK_2cmt_des | Two compartment PK model with linear clearance using differential equations |
| PK_2cmt_no_depot | Two compartment PK model with linear clearance using differential equations |
| PK_2cmt_tdcl_des | Two compartment PK model with time-dependent clearance using differential equations (structured like nivolumab PK model) |
| PK_3cmt | Three compartment PK model with linear clearance |
| PK_3cmt_des | Three compartment PK model with linear clearance using differential equations |
| phenylalanine_charbonneau_2021 | Phenylalanine model for absorption and metabolism in healthy subjects and patients with PKU |
| indirect_0cpt_transitEx | Two compartment PK model with Michealis-Menten clearance using differential equations |
| indirect_1cpt_inhi_kin | One compartment indirect response model with inhibition of kin. |
| indirect_1cpt_inhi_kin_CLV | One compartment indirect response model with inhibition of kin. |
| indirect_1cpt_inhi_kin_r0rmaxcrmax | One compartment indirect response model with inhibition of kin. |
| indirect_1cpt_inhi_kout | One compartment indirect response model with inhibition of kout. |
| indirect_1cpt_inhi_kout_CLV | One compartment indirect response model with inhibition of kout. |
| indirect_1cpt_inhi_kout_r0rmaxcrmax | One compartment indirect response model with inhibition of kout. |
| indirect_1cpt_stim_kin | One compartment indirect response model with stimulation of kin.Parameterized using rate cosntants |
| indirect_1cpt_stim_kin_CLV | One compartment indirect response model with stimulation of kin. |
| indirect_1cpt_stim_kin_r0rmaxcrmax | One compartment indirect response model with stimulation of kin. |
| indirect_1cpt_stim_kout | One compartment indirect response model with stimulation of kout.Parameterized using rate cosntants |
| indirect_1cpt_stim_kout_CLV | One compartment indirect response model with stimulation of kout. |
| indirect_1cpt_stim_kout_r0rmaxcrmax | One compartment indirect response model with stimulation of kout. |
| indirect_circ_1cpt_inhi_kin_kin_t | One compartment indirect response model with inhibition of kin and circadian kin_t. |
| indirect_circ_1cpt_inhi_kin_kout_t | One compartment indirect response model with inhibition of kin and circadian kin_t. |
| indirect_circ_1cpt_inhi_kout_kin_t | One compartment indirect response model with inhibition of kout and circadian kin_t. |
| indirect_circ_1cpt_inhi_kout_kout_t | One compartment indirect response model with inhibition of kout and circadian kin_t. |
| indirect_circ_1cpt_stim_kin_kin_t | One compartment indirect response model with stimulation of kin and circadian kin_t.Parameterized using rate cosntants |
| indirect_circ_1cpt_stim_kin_kout_t | One compartment indirect response model with stimulation of kin and circadian kout_t.Parameterized using rate constants |
| indirect_circ_1cpt_stim_kout_kin_t | One compartment indirect response model with stimulation of kout and circadian kin_t.Parameterized using rate cosntants |
| indirect_circ_1cpt_stim_kout_kout_t | One compartment indirect response model with stimulation of kout and circadian kout_t.Parameterized using rate cosntants |
| indirect_prec_1cpt_inhi_CLV | One compartment precursor-dependent indirect response model with inhibition of drug response. Parameterized with clearance and volume. (effect). |
| indirect_prec_1cpt_inhi_r0rmaxcrmax | One compartment precursor-dependent indirect response model with inhibition of drug response (effect). |
| indirect_prec_1cpt_stim_CLV | One compartment precursor-dependent indirect response model with inhibition of drug response (effect). Parameterized with clearance and volume |
| indirect_prec_1cpt_stim_r0rmaxcrmax | One compartment precursor-dependent indirect response model with inhibition of drug response (effect). Parameterized with clearance and volume |
| PK_2cmt_mAb_Davda_2014 | Two compartment PK model with linear clearance for average monoclonal antibodies (Davda 2014) |
| PK_double_sim_01 | PK double absorption model with simultaneous zero order and first order absorptions |
| PK_double_sim_10 | PK double absorption model with simultaneous first order and zero order absorptions |
| PK_double_sim_11 | PK double absorption model with simultaneous first order absorptions |
| CarlssonPetri_2021_liraglutide | Liraglutide PK model in adolescents (Carlsson Petri 2021) |
| Cirincione_2017_exenatide | Exenatide immediate-release PK model (Cirincione 2017) |
| Kovalenko_2020_dupilumab | Dupilumab PK model (Kovalenko 2020) |
| Soehoel_2022_tralokinumab | Tralokinumab PK model (Soehoel 2022) |
| Zhu_2017_lebrikizumab | Lebrikizumab PK model (Zhu 2017) |
| oncology_sdm_lobo_2002 | Signal transduction model for delayed concentration effects on cancer cell growth |
| oncology_xenograft_simeoni_2004 | Oncology tumor growth model in xenograft models |
| tgi_no_sat_Koch | One compartment TGI model with with exponential tumor growth, without saturation. |
| tgi_no_sat_expo | One compartment TGI model with with exponential tumor growth, without saturation. |
| tgi_no_sat_linear | One compartment TGI model with with linear tumor growth, without saturation. |
| tgi_no_sat_powerLaw | One compartment TGI model with with exponential tumor growth, without saturation. |
| tgi_sat_VonBertalanffy | One compartment TGI model where tumor growth is limited by a loss term, with saturation. |
| tgi_sat_genVonBertalanffy | One compartment TGI model where tumor growth is limited by a loss term, with saturation. |
| tgi_sat_logistic | One compartment TGI model with with exponential tumor growth that decelerates linearly, with saturation. |
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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