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The multilevelmod package is a parsnip extension package for multi-level models, which are also known as mixed-effects models, Bayesian hierarchical models, etc. The models wrapped by the multilevelmod package tend to have somewhat different interfaces than the average R modeling package, mostly due to how random effects and independent experimental units are specified.

This vignette is an overview of how to fit these models. For brevity, we only discuss linear models but the syntax also works for binomial, multinomial, and Poisson outcomes.

library(tidymodels)
library(multilevelmod)

tidymodels_prefer()
theme_set(theme_bw())

We’ll use some single factor repeated measures experiment data from the lme4 package, on the effect of sleep deprivation on reaction time.

data(sleepstudy, package = "lme4")

sleepstudy %>% 
  ggplot(aes(x = Days, y = Reaction)) + 
  geom_point() + 
  geom_line() +
  facet_wrap(~ Subject) 

To show how prediction works, let’s create a new data frame for a hypothetical subject “one”:

new_subject <- tibble(
  Days = 0:9, 
  Subject = "one"
)

Now let’s look at how the modeling engines work with multilevelmod.

Generalized estimator equations (GEE)

This engine requires the gee package to be installed.

There are no random effects in this model. Like the generalized least squares model discussed below, this model deals with the within-subject correlations by estimating a correlation (or covariance) matrix that is not diagonal. To do this, the model formula should use the id_var() function. This is a special syntax for creating model matrices (there is no actual id_var() function) that designates the column for the independent experimental unit.

The correlation structure can be passed as an engine argument:

gee_spec <- 
  linear_reg() %>% 
  set_engine("gee", corstr = "exchangeable")

gee_fit <- 
  gee_spec %>% 
  fit(Reaction ~ Days + id_var(Subject), data = sleepstudy)
## Beginning Cgee S-function, @(#) geeformula.q 4.13 98/01/27
## running glm to get initial regression estimate
gee_fit
## parsnip model object
## 
## 
##  GEE:  GENERALIZED LINEAR MODELS FOR DEPENDENT DATA
##  gee S-function, version 4.13 modified 98/01/27 (1998) 
## 
## Model:
##  Link:                      Identity 
##  Variance to Mean Relation: Gaussian 
##  Correlation Structure:     Exchangeable 
## 
## Call:
## gee::gee(formula = Reaction ~ Days, id = data$Subject, data = data, 
##     family = gaussian, corstr = "exchangeable")
## 
## Number of observations :  180 
## 
## Maximum cluster size   :  10 
## 
## 
## Coefficients:
## (Intercept)        Days 
##   251.40510    10.46729 
## 
## Estimated Scale Parameter:  2276.694
## Number of Iterations:  1
## 
## Working Correlation[1:4,1:4]
##           [,1]      [,2]      [,3]      [,4]
## [1,] 1.0000000 0.5710385 0.5710385 0.5710385
## [2,] 0.5710385 1.0000000 0.5710385 0.5710385
## [3,] 0.5710385 0.5710385 1.0000000 0.5710385
## [4,] 0.5710385 0.5710385 0.5710385 1.0000000
## 
## 
## Returned Error Value:
## [1] 0

Only a single column name can be given to id_var().

When predicting, the id_var column is not required:

predict(gee_fit, new_subject %>% select(Days)) %>% 
  bind_cols(new_subject)
## # A tibble: 10 × 3
##    .pred  Days Subject
##    <dbl> <int> <chr>  
##  1  251.     0 one    
##  2  262.     1 one    
##  3  272.     2 one    
##  4  283.     3 one    
##  5  293.     4 one    
##  6  304.     5 one    
##  7  314.     6 one    
##  8  325.     7 one    
##  9  335.     8 one    
## 10  346.     9 one

Generalized least squares

This engine requires the nlme package to be installed.

For this model, the syntax to specify the independent experimental unit is inside of the corrrelation argument for nlme::gls(). We’ll pass that as an engine argument. Possible values can be found using ?nlme::corStruct.

For example:

library(nlme) # <- Only need to load this to get cor*() functions

gls_spec <- 
  linear_reg() %>% 
  set_engine("gls", correlation = corCompSymm(form = ~ 1 | Subject))

gls_fit <- 
  gls_spec %>% 
  fit(Reaction ~ Days, data = sleepstudy)

gls_fit
## parsnip model object
## 
## Generalized least squares fit by REML
##   Model: Reaction ~ Days 
##   Data: data 
##   Log-restricted-likelihood: -893.2325
## 
## Coefficients:
## (Intercept)        Days 
##   251.40510    10.46729 
## 
## Correlation Structure: Compound symmetry
##  Formula: ~1 | Subject 
##  Parameter estimate(s):
##       Rho 
## 0.5893103 
## Degrees of freedom: 180 total; 178 residual
## Residual standard error: 48.3595

As with the GEE model, only the regression terms are required for prediction:

predict(gls_fit, new_subject %>% select(Days)) %>% 
  bind_cols(new_subject)
## # A tibble: 10 × 3
##    .pred  Days Subject
##    <dbl> <int> <chr>  
##  1  251.     0 one    
##  2  262.     1 one    
##  3  272.     2 one    
##  4  283.     3 one    
##  5  293.     4 one    
##  6  304.     5 one    
##  7  314.     6 one    
##  8  325.     7 one    
##  9  335.     8 one    
## 10  346.     9 one

Linear mixed effects via lme

This engine requires the nlme package to be installed.

For models created by nlme::lme(), the random effects are specified in an argument called random. This can be passed via set_engine(). The formula specified for fit() should only include the fixed effects for the model.

To fit the basic random intercept model:

lme_spec <- 
  linear_reg() %>% 
  set_engine("lme", random = ~ 1 | Subject)

lme_fit <- 
  lme_spec %>% 
  fit(Reaction ~ Days, data = sleepstudy)

lme_fit
## parsnip model object
## 
## Linear mixed-effects model fit by REML
##   Data: data 
##   Log-restricted-likelihood: -893.2325
##   Fixed: Reaction ~ Days 
## (Intercept)        Days 
##   251.40510    10.46729 
## 
## Random effects:
##  Formula: ~1 | Subject
##         (Intercept) Residual
## StdDev:    37.12383 30.99123
## 
## Number of Observations: 180
## Number of Groups: 18

For predictions, tidymodels uses only the “population effects”, i.e., no-subject specific random effects. We have designed tidymodels so that you should not know about the specific training set values when making any type of prediction.

For lme fit objects, the subject column, if given, is ignored. When the underlying predict() function is used, the level = 0 argument is automatically invoked:

predict(lme_fit, new_subject) %>% 
  bind_cols(new_subject)
## # A tibble: 10 × 3
##    .pred  Days Subject
##    <dbl> <int> <chr>  
##  1  251.     0 one    
##  2  262.     1 one    
##  3  272.     2 one    
##  4  283.     3 one    
##  5  293.     4 one    
##  6  304.     5 one    
##  7  314.     6 one    
##  8  325.     7 one    
##  9  335.     8 one    
## 10  346.     9 one
# For this design, this is the same prediction as a training set point:
predict(lme_fit, sleepstudy %>% filter(Subject == "308"))
## # A tibble: 10 × 1
##    .pred
##    <dbl>
##  1  251.
##  2  262.
##  3  272.
##  4  283.
##  5  293.
##  6  304.
##  7  314.
##  8  325.
##  9  335.
## 10  346.

Models using lmer, glmer, and stan_glmer

The "lmer", "glmer", and "stan_glmer" engines all use the same formula syntax for fitting multilevel models. See Section 2.1 of Linear Mixed Models with lme4 for details. In this section, we’ll demonstrate using the "lmer" engine.

All of the model specification occurs in the formula; no models terms are specified via set_engine() (although other arguments can be passed there, as usual). To fit the same random intercept model, the syntax is:

lmer_spec <- 
  linear_reg() %>% 
  set_engine("lmer")

lmer_fit <- 
  lmer_spec %>% 
  fit(Reaction ~ Days + (1|Subject), data = sleepstudy)

lmer_fit
## parsnip model object
## 
## Linear mixed model fit by REML ['lmerMod']
## Formula: Reaction ~ Days + (1 | Subject)
##    Data: data
## REML criterion at convergence: 1786.465
## Random effects:
##  Groups   Name        Std.Dev.
##  Subject  (Intercept) 37.12   
##  Residual             30.99   
## Number of obs: 180, groups:  Subject, 18
## Fixed Effects:
## (Intercept)         Days  
##      251.41        10.47

We predict in the same way.

predict(lmer_fit, new_subject) %>% 
  bind_cols(new_subject)
## # A tibble: 10 × 3
##    .pred  Days Subject
##    <dbl> <int> <chr>  
##  1  251.     0 one    
##  2  262.     1 one    
##  3  272.     2 one    
##  4  283.     3 one    
##  5  293.     4 one    
##  6  304.     5 one    
##  7  314.     6 one    
##  8  325.     7 one    
##  9  335.     8 one    
## 10  346.     9 one

To determine what packages are required for a model, use this function:

required_pkgs(lmer_spec)
## [1] "parsnip"       "lme4"          "multilevelmod"

For the "stan_glmer" engine, some relevant arguments that can be passed to set_engine() are:

See ?rstanarm::stan_glmer and ?rstan::sampling for more information.

Using tidymodels workflows

If you use workflows, we have a few suggestions.

First, instead of using add_formula(), we suggest using add_variables(). This passes the columns as-is to the model fitting function. To add the random effects formula, use the formula argument of add_model(). For example:

lmer_wflow <- 
  workflow() %>% 
  add_variables(outcomes = Reaction, predictors = c(Days, Subject)) %>% 
  add_model(lmer_spec, formula = Reaction ~ Days + (1|Subject))

lmer_wflow %>% fit(data = sleepstudy)
## ══ Workflow [trained] ══════════════════════════════════════════════════════════
## Preprocessor: Variables
## Model: linear_reg()
## 
## ── Preprocessor ────────────────────────────────────────────────────────────────
## Outcomes: Reaction
## Predictors: c(Days, Subject)
## 
## ── Model ───────────────────────────────────────────────────────────────────────
## Linear mixed model fit by REML ['lmerMod']
## Formula: Reaction ~ Days + (1 | Subject)
##    Data: data
## REML criterion at convergence: 1786.465
## Random effects:
##  Groups   Name        Std.Dev.
##  Subject  (Intercept) 37.12   
##  Residual             30.99   
## Number of obs: 180, groups:  Subject, 18
## Fixed Effects:
## (Intercept)         Days  
##      251.41        10.47

If using a recipe, make sure that functions like step_dummy() do not convert the column for the independent experimental unit (i.e. subject) to dummy variables. The underlying model fit functions require a single column for these data.

Using a recipe also offers the opportunity to set a different role for the independent experiment unit, which can come in handy when more complex preprocessing is needed.

rec <- 
  recipe(Reaction ~ Days + Subject, data = sleepstudy) %>%
  add_role(Subject, new_role = "exp_unit") %>%
  step_zv(all_predictors(), -has_role("exp_unit"))

lmer_wflow %>%
  remove_variables() %>%
  add_recipe(rec) %>%
  fit(data = sleepstudy)
## ══ Workflow [trained] ══════════════════════════════════════════════════════════
## Preprocessor: Recipe
## Model: linear_reg()
## 
## ── Preprocessor ────────────────────────────────────────────────────────────────
## 1 Recipe Step
## 
## • step_zv()
## 
## ── Model ───────────────────────────────────────────────────────────────────────
## Linear mixed model fit by REML ['lmerMod']
## Formula: Reaction ~ Days + (1 | Subject)
##    Data: data
## REML criterion at convergence: 1786.465
## Random effects:
##  Groups   Name        Std.Dev.
##  Subject  (Intercept) 37.12   
##  Residual             30.99   
## Number of obs: 180, groups:  Subject, 18
## Fixed Effects:
## (Intercept)         Days  
##      251.41        10.47

Other tips

Finally, there are excellent helper functions in the broom.mixed and tidybayes packages. If these need the underlying model fit object: the extract_fit_engine() function can be used on either parsnip or workflow objects:

lmer_wflow %>% 
  fit(data = sleepstudy) %>% # <- returns a workflow
  extract_fit_engine()       # <- returns the lmer object
## Linear mixed model fit by REML ['lmerMod']
## Formula: Reaction ~ Days + (1 | Subject)
##    Data: data
## REML criterion at convergence: 1786.465
## Random effects:
##  Groups   Name        Std.Dev.
##  Subject  (Intercept) 37.12   
##  Residual             30.99   
## Number of obs: 180, groups:  Subject, 18
## Fixed Effects:
## (Intercept)         Days  
##      251.41        10.47

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