idem: Inference in Randomized Controlled Trials with Death and Missingness

In randomized studies involving severely ill patients, functional outcomes are often unobserved due to missed clinic visits, premature withdrawal or death. It is well known that if these unobserved functional outcomes are not handled properly, biased treatment comparisons can be produced. In this package, we implement a procedure for comparing treatments that is based on the composite endpoint of both the functional outcome and survival. The procedure was proposed in Wang et al. (2016) <doi:10.1111/biom.12594> and Wang et al. (2020) <doi:10.18637/jss.v093.i12>. It considers missing data imputation with different sensitivity analysis strategies to handle the unobserved functional outcomes not due to death.

Version:	5.2
Depends:	R (≥ 3.4.0), Rcpp (≥ 0.12.0), methods
Imports:	rstan (≥ 2.18.1), RcppParallel (≥ 5.0.1), rstantools (≥ 2.1.1), sqldf (≥ 0.4), survival (≥ 2.38), mice (≥ 3.9.0), parallel (≥ 3.2)
LinkingTo:	StanHeaders (≥ 2.18.0), rstan (≥ 2.18.1), BH (≥ 1.66.0), Rcpp (≥ 0.12.0), RcppEigen (≥ 0.3.3.3.0), RcppParallel (≥ 5.0.1)
Suggests:	knitr, shiny, rmarkdown, pander, DT, shinythemes
Published:	2023-08-09
DOI:	10.32614/CRAN.package.idem
Author:	Chenguang Wang [aut, cre], Andrew Leroux [aut, cre], Elizabeth Colantuoni [aut], Daniel O Scharfstein [aut], Trustees of Columbia University [cph] (tools/make_cpp.R, R/stanmodels.R)
Maintainer:	Chenguang Wang <cwang68 at jhmi.edu>
License:	GPL (≥ 3)
URL:	https://github.com/olssol/idem/
NeedsCompilation:	yes
SystemRequirements:	GNU make
Citation:	idem citation info
Materials:	NEWS
In views:	CausalInference
CRAN checks:	idem results

Documentation:

Reference manual:	idem.pdf
Vignettes:	idem: Inference in Randomized Controlled Trials with Death and Missingness

Downloads:

Package source:	idem_5.2.tar.gz
Windows binaries:	r-devel: idem_5.2.zip, r-release: idem_5.2.zip, r-oldrel: idem_5.2.zip
macOS binaries:	r-release (arm64): idem_5.2.tgz, r-oldrel (arm64): idem_5.2.tgz, r-release (x86_64): idem_5.2.tgz, r-oldrel (x86_64): idem_5.2.tgz
Old sources:	idem archive

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