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ec50estimator: EC50 workflows for multi-isolate dose-response experiments

ec50estimator helps scientists estimate EC50 from grouped dose-response datasets. It wraps the modelling engine from drc in a workflow that is easier to use for experiments with many isolates, fields, fungicides, years, or other strata.

The package is built around one practical sequence:

  1. Check whether the dose-response data are fit-ready.
  2. Fit one model or compare several candidate models.
  3. Inspect fit quality and failed fits.
  4. Plot fitted curves with ggplot2.
  5. Extract predictions, curve coordinates, and manuscript-ready EC50 tables.

Installation

Install the stable release from CRAN.

install.packages("ec50estimator")

Install the development version from GitHub.

pak::pak("AlvesKS/ec50estimator")

Quick Start

library(ec50estimator)
library(drc)

data(multi_isolate)

example_data <- subset(
  multi_isolate,
  isolate %in% 1:5 & fungicida == "Fungicide A"
)

check_ec50_data(
  example_data,
  response = "growth",
  dose = "dose",
  isolate = "isolate",
  strata = "field"
)

fit <- ec50_multimodel(
  growth ~ dose,
  data = example_data,
  isolate_col = "isolate",
  strata_col = "field",
  fct = list(drc::LL.3(), drc::LL.4(), drc::W2.3()),
  interval = "delta"
)

best_model(fit)
plot_EC50_curves(fit, models = "best")
report_ec50(fit, models = "best")

fit is still a data frame, so existing workflows that call head(fit) or write the estimates to a file continue to work. It also stores the fitted drc models and metadata needed by helper functions:

curve_data(fit)
fitted_models(fit)
ec50_metadata(fit)
predict_ec50(fit, dose = c(0.001, 0.01, 0.1), models = "best")
plot_residuals(fit, models = "best")

See the pkgdown site for the recommended workflow: https://alvesks.github.io/ec50estimator/.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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