The hardware and bandwidth for this mirror is donated by dogado GmbH, the Webhosting and Full Service-Cloud Provider. Check out our Wordpress Tutorial.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]dogado.de.

Compare_to_original_BOIN

library(bfboin)

A good starting point to test that get.oc.bf() is working as expected is that it should produce the same result (within simulation error) as BOIN::get.oc() when the response rates are all set to zero (thus effectively turning off the backfilling component of the design).

get.oc.bf(ntrial = 10000,
          seed = 9,
          target = 0.25,
          p.true = c(0.1, 0.5),
          ncohort = 10,
          cohortsize = 3,
          n.earlystop = 9,
          startdose = 1,
          titration = FALSE,
          cutoff.eli = 0.95,
          extrasafe = TRUE,
          offset = 0.1,
          boundMTD=FALSE,
          n.cap = 12,
          end.backfill = TRUE,
          n.per.month = 1,
          dlt.window = 1,
          p.response.true = c(0.00001, 0.00001))
#> $selpercent
#> [1] 77.91 17.91
#> 
#> $npatients
#>       1       2 
#> 10.8288  7.6767 
#> 
#> $percentpatients
#>        1        2 
#> 58.51666 41.48334 
#> 
#> $ntox
#>      1      2 
#> 1.0852 3.8624 
#> 
#> $totaltox
#> [1] 4.9476
#> 
#> $totaln
#> [1] 18.5055
#> 
#> $percentstop
#> [1] 4.18
#> 
#> $duration
#> [1] 21.30958


BOIN::get.oc(target = 0.25,
             p.true = c(0.1, 0.5),
             ncohort = 10,
             cohortsize = 3,
             n.earlystop = 9,
             startdose = 1,
             titration = FALSE,
             cutoff.eli = 0.95,
             extrasafe = TRUE,
             offset = 0.1,
             boundMTD=FALSE,
             ntrial = 10000, seed = 6)
#> $selpercent
#> [1] 77.75 18.42
#> 
#> $npatients
#> [1] 10.7160  7.7784
#> 
#> $ntox
#> [1] 1.0536 3.8988
#> 
#> $totaltox
#> [1] 4.9524
#> 
#> $totaln
#> [1] 18.4944
#> 
#> $percentstop
#> [1] 3.83
#> 
#> $simu.setup
#>   target p.true ncohort cohortsize startdose p.saf p.tox cutoff.eli extrasafe
#> 1   0.25    0.1      10          3         1  0.15  0.35       0.95      TRUE
#> 2   0.25    0.5      10          3         1  0.15  0.35       0.95      TRUE
#>   offset ntrial dose
#> 1    0.1  10000    1
#> 2    0.1  10000    2
#> 
#> $flowchart
#> [1] TRUE
#> 
#> $lambda_e
#> [1] 0.1968009
#> 
#> $lambda_d
#> [1] 0.2983922
#> 
#> attr(,"class")
#> [1] "boin"

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.