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Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.
| Version: | 0.1.2 |
| Depends: | R (≥ 3.5.0) |
| Imports: | Rcpp (≥ 0.12.17) |
| LinkingTo: | Rcpp (≥ 0.12.17) |
| Suggests: | knitr, rmarkdown |
| Published: | 2022-12-09 |
| DOI: | 10.32614/CRAN.package.adpss |
| Author: | Kosuke Kashiwabara [aut, cre] |
| Maintainer: | Kosuke Kashiwabara <kashiwabara-tky at umin.ac.jp> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| URL: | https://github.com/ca4wa/R-adpss |
| NeedsCompilation: | yes |
| Materials: | README NEWS |
| CRAN checks: | adpss results |
| Reference manual: | adpss.pdf |
| Vignettes: |
Illustration of adaptive sample size determination |
| Package source: | adpss_0.1.2.tar.gz |
| Windows binaries: | r-devel: adpss_0.1.2.zip, r-release: adpss_0.1.2.zip, r-oldrel: adpss_0.1.2.zip |
| macOS binaries: | r-release (arm64): adpss_0.1.2.tgz, r-oldrel (arm64): adpss_0.1.2.tgz, r-release (x86_64): adpss_0.1.2.tgz, r-oldrel (x86_64): adpss_0.1.2.tgz |
| Old sources: | adpss archive |
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These binaries (installable software) and packages are in development.
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