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Adaptive optimal two-stage designs for clinical trials with one or two arms. For details on the core theoretical background, see:
Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs. Statistics in Medicine. 2019;38(21):4159–4171. https://doi.org/10.1002/sim.8291
Install the latest CRAN release via
install.packages("adoptr")
and the development version directly from GitHub with:
::install_github("optad/adoptr") devtools
The documentation is hosted at https://optad.github.io/adoptr.
We provide an extensive validation report for adoptr which is implemented using the bookdown package. The sources are available at https://github.com/optad/adoptr-validation-report and the last build version is hosted at https://optad.github.io/adoptr-validation-report.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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