The hardware and bandwidth for this mirror is donated by dogado GmbH, the Webhosting and Full Service-Cloud Provider. Check out our Wordpress Tutorial.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]dogado.de.
This package implements methods to evaluate the performance characteristics of various point and interval estimators for adaptive two-stage designs with prespecified sample-size recalculation rules. Further, it allows for evaluation of these estimators on real datasets, and it implements methods to calculate p-values.
Currently, it works for designs objects which were produced by the
R-package adoptr
, which calculates optimal design
parameters adaptive two-stage designs.
You can install the development version of adestr by typing
::install_github("https://github.com/jan-imbi/adestr") remotes
into your R console.
The scripts to reproduce the results from the paper can be found in
the /data/code/
directory of this repository. The results
themselves are located in the /data/
directory.
The easiest way to inspect the results is to clone this repository.
Here is a quick example showing the capabilities of
adestr
. First, load adestr
:
library(adestr)
Then, you can evaluate the performance of an estimator like this:
evaluate_estimator(
score = MSE(),
estimator = SampleMean(),
data_distribution = Normal(two_armed = TRUE),
design = get_example_design(),
mu = c(0, 0.3, 0.6),
sigma = 1
)#> Design: TwoStageDesign<n1=28;0.8<=x1<=2.3:n2=9-40>
#> Data Distribution: Normal<two-armed>
#> Estimator: Sample mean
#> Assumed sigma: 1
#> Assumed mu: 0.0 0.3 0.6
#> Results:
#> Expectation: -0.0352411 0.2816994 0.6355803
#> Bias: -0.03524110 -0.01830056 0.03558030
#> Variance: 0.05558372 0.07330105 0.06590990
#> MSE: 0.05682565 0.07363596 0.06717585
evaluate_estimator(
score = MSE(),
estimator = SampleMean(),
data_distribution = Normal(two_armed = TRUE),
design = get_example_design(),
mu = seq(-0.7, 1.5, .05),
sigma = 1
|>
) plot()
You can analyze a dataset like this:
set.seed(321)
<- data.frame(
dat endpoint = c(rnorm(28, .2, 1), rnorm(28, 0, 1),
rnorm(23, .2, 1), rnorm(23, 0, 1)),
group = factor(rep(c("ctl", "trt", "ctl", "trt"),
c(28,28,23,23))),
stage = rep(c(1L, 2L), c(56, 46))
)analyze(
data = dat,
statistics = get_example_statistics(),
data_distribution = Normal(two_armed = TRUE),
sigma = 1,
design = get_example_design()
)#> Design: TwoStageDesign<n1=28;0.8<=x1<=2.3:n2=9-40>
#> Data Distribution: Normal<two-armed>
#> Observed number of stages: 2
#> Observed n1 (group 1) 28
#> Observed n1 (group 2) 28
#> Observed n1 (total) 56
#> Z1 1.75
#> Interim decision: continue to second stage
#> Calculated n2(Z1) (per group) 23.49151
#> Calculated c2(Z1) 1.14
#> Observed n2 (group 1) 23
#> Observed n2 (group 2) 23
#> Observed n2 (in total) 46
#> Z2 2.12
#> Final test decision: reject null
#>
#> Stage 2 results:
#> Sample mean: 0.5389012
#> Pseudo Rao-Blackwellized: 0.3632916
#> Median unbiased (LR test ordering): 0.5069941
#> Bias reduced MLE (iterations=1): 0.5253942
#> SWCF ordering CI: [0.06264641, 0.7429735]
#> LR test ordering CI: [0.2509094, 0.81829]
#> SWCF ordering p-value: 0.01097483
#> LR test ordering p-value: 6.653031e-05
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.