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2023-01-29
In the past decade, genome-scale metabolic reconstructions have widely been used to comprehend the systems biology of metabolic pathways within an organism. Different GSMs are constructed using various techniques that require distinct steps, but the input data, information conversion and software tools are neither concisely defined nor mathematically or programmatically formulated in a context-specific manner.The tool that quantitatively and qualitatively specifies each reconstruction steps and can generate a template list of reconstruction steps dynamically selected from a reconstruction step reservoir, constructed based on all available published papers.
install.packages('Sysrecon')
library(Sysrecon)To visualize the steps, databases and tools used in the genome-scale metabolic reconstruction, We need eight types of data as inputs - inputTxt, stepsMatrix, stepTypes, conversionMatrix, conversionTypes, toolsMatrix, toolsTypes and contentTypes.
inputTxt is a variable that contains the contents of the metabolic reconstruction in an article and there is an example of the inputTxt in the Sysrecon package.
inputTxt = Sysrecon::inputTxt
If you want to analyze another article, you can import the article to the R.
inputTxt = read.table(path, fill = T, sep = '\n', quote = "")The other seven types of data are in the package and all of them are data frame types. stepsMatrix contains the details of the steps of the metabolic reconstruction and stepTypes is a data frame contains the labels and groups of the stepsMatrix. conversionMatrix contains the details of the transformation of the metabolic reconstruction and conversionTypes contains the labels and groups of the conversionMatrix. toolsMatrix contains the details of the databases and tools of the metabolic reconstruction and toolsTypes contains the labels and groups of toolsMatrix. Finally, contentTypes contains the labels and groups of the contents of metabolic reconstruction.
stepsMatrix = Sysrecon::stepsMatrix
stepTypes = Sysrecon::stepTypes
conversionMatrix = Sysrecon::conversionMatrix
conversionTypes = Sysrecon::conversionTypes
toolsMatrix = Sysrecon::toolsMatrix
toolsTypes = Sysrecon::toolsTypes
contentTypes = Sysrecon::contentTypes
When all of data needed are prepared, the Sysrecon package can be used.
Sysrecon(inputTxt, stepsMatrix, stepTypes, conversionMatrix, conversionTypes, toolsMatrix, toolsTypes, contentTypes)This will generates three pictures and an output. The three pictures are the visualization of the steps, transformation, and databases and tools of the metabolic reconstruction, respectively. And the output is like the chemical formula to facilitate understanding the steps and elements needed in a step.
Besides Sysrecon can visualize the steps of the metabolic reconstruction, so does the function vizProcess. In addition, vizProcess also can generates the output that contains chemical-like steps.
text = paste0(inputTxt[,1], collapse = ' ')
vizProcess(text, stepsMatrix, stepTypes, contentTypes)The function vizTransformation is a function specifically for visualizing the transformation of the metabolic reconstruction.
text = paste0(inputTxt[,1], collapse = ' ')
vizTransformation(text, conversionMatrix, stepTypes, conversionTypes)The function vizTransformation is a function specifically for visualizing the databases and tools used in the metabolic reconstruction.
text = paste0(inputTxt[,1], collapse = ' ')
vizTools(text, toolsMatrix, stepTypes, toolsTypes)sessionInfo()
# R version 4.2.2 (2022-10-31 ucrt)
# Platform: x86_64-w64-mingw32/x64 (64-bit)
# Running under: Windows 10 x64 (build 22000)
#
# Matrix products: default
#
# locale:
# [1] LC_COLLATE=Chinese (Simplified)_China.utf8 LC_CTYPE=Chinese (Simplified)_China.utf8
# [3] LC_MONETARY=Chinese (Simplified)_China.utf8 LC_NUMERIC=C
# [5] LC_TIME=Chinese (Simplified)_China.utf8
#
# attached base packages:
# [1] stats graphics grDevices utils datasets methods base
#
# other attached packages:
# [1] Sysrecon_0.1.2 pkgdown_2.0.7 devtools_2.4.5 usethis_2.1.6
#
# loaded via a namespace (and not attached):
# [1] nlme_3.1-160 fs_1.5.2 ggtree_3.6.2 lubridate_1.9.0 httr_1.4.4
# [6] RColorBrewer_1.1-3 rprojroot_2.0.3 SnowballC_0.7.0 tools_4.2.2 profvis_0.3.7
# [11] backports_1.4.1 utf8_1.2.2 R6_2.5.1 DBI_1.1.3 lazyeval_0.2.2
# [16] colorspace_2.0-3 urlchecker_1.0.1 withr_2.5.0 tidyselect_1.2.0 prettyunits_1.1.1
# [21] processx_3.8.0 compiler_4.2.2 rvest_1.0.3 cli_3.4.1 NLP_0.2-1
# [26] xml2_1.3.3 desc_1.4.2 slam_0.1-50 scales_1.2.1 tm_0.7-9
# [31] readr_2.1.3 callr_3.7.3 stringr_1.4.1 digest_0.6.30 yulab.utils_0.0.5
# [36] rmarkdown_2.18 pkgconfig_2.0.3 htmltools_0.5.3 sessioninfo_1.2.2 dbplyr_2.2.1
# [41] fastmap_1.1.0 htmlwidgets_1.5.4 rlang_1.0.6 readxl_1.4.1 rstudioapi_0.14
# [46] shiny_1.7.3 gridGraphics_0.5-1 generics_0.1.3 jsonlite_1.8.3 googlesheets4_1.0.1
# [51] dplyr_1.0.10 magrittr_2.0.3 ggplotify_0.1.0 patchwork_1.1.2 Rcpp_1.0.9
# [56] munsell_0.5.0 fansi_1.0.3 ape_5.6-2 lifecycle_1.0.3 stringi_1.7.8
# [61] yaml_2.3.6 pkgbuild_1.3.1 plyr_1.8.8 grid_4.2.2 parallel_4.2.2
# [66] promises_1.2.0.1 forcats_0.5.2 crayon_1.5.2 miniUI_0.1.1.1 lattice_0.20-45
# [71] haven_2.5.1 hms_1.1.2 knitr_1.41 ps_1.7.2 pillar_1.8.1
# [76] pkgload_1.3.2 reprex_2.0.2 glue_1.6.2 evaluate_0.18 ggfun_0.0.9
# [81] BiocManager_1.30.19 modelr_0.1.10 remotes_2.4.2 vctrs_0.5.0 treeio_1.22.0
# [86] tzdb_0.3.0 httpuv_1.6.6 cellranger_1.1.0 gtable_0.3.1 purrr_0.3.5
# [91] tidyr_1.2.1 assertthat_0.2.1 cachem_1.0.6 ggplot2_3.4.0 xfun_0.34
# [96] mime_0.12 xtable_1.8-4 broom_1.0.1 tidyverse_1.3.2 tidytree_0.4.1
# [101] roxygen2_7.2.2 later_1.3.0 googledrive_2.0.0 gargle_1.2.1 tibble_3.1.8
# [106] aplot_0.1.9 memoise_2.0.1 timechange_0.1.1 ellipsis_0.3.2 These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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