SPINA: Structure Parameter Inference Approach
SPINA (Structure Parameter Inference Approach) is a methodology to calculate constant structure parameters of endocrine homeostatic systems from steady-state hormone and metabolite concentrations. Methods and equations for thyroid homeostasis (SPINA Thyr) have been described in Dietrich et al. (2012) <doi:10.1155/2012/351864> and Dietrich et al. (2016) <doi:10.3389/fendo.2016.00057>, and for glucose homeostasis (SPINA Carb) in Dietrich et al. (2022) <doi:10.1038/s41598-022-22531-3> and Dietrich et al. (2024) <doi:10.1111/1753-0407.13525>.
| Version: | 5.1.0 |
| Depends: | R (≥ 3.5) |
| Suggests: | knitr, rmarkdown, testthat (≥ 3.0.0) |
| Published: | 2026-09-16 |
| DOI: | 10.32614/CRAN.package.SPINA |
| Author: | Johannes W. Dietrich
 [aut, cph,
cre],
Eleni Karamitrou
[ctb],
Bernhard O. Boehm
[ctb] |
| Maintainer: | Johannes W. Dietrich <johannes.dietrich at ruhr-uni-bochum.de> |
| BugReports: | https://sourceforge.net/p/spina/bugs/ |
| License: | BSD_3_clause + file LICENSE |
| URL: | https://spina.sourceforge.net |
| NeedsCompilation: | no |
| Citation: | SPINA citation info |
| Materials: | README |
| CRAN checks: | SPINA results |
Documentation:
| Reference manual: | SPINA.html , SPINA.pdf |
| Vignettes: |
Handbook and Reference for SPINA (source, R code) |
Downloads:
| Package source: | SPINA_5.1.0.tar.gz |
| Windows binaries: | r-devel: SPINA_5.1.0.zip, r-release: SPINA_4.1.0.zip, r-oldrel: SPINA_5.1.0.zip |
| macOS binaries: | r-release (arm64): SPINA_5.1.0.tgz, r-oldrel (arm64): SPINA_5.1.0.tgz, r-release (x86_64): SPINA_5.1.0.tgz, r-oldrel (x86_64): SPINA_5.1.0.tgz |
| Old sources: | SPINA archive |
Linking:
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