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An R interface for processing concentration-response datasets using Curvep, a response noise filtering algorithm. The algorithm was described in the publications (Sedykh A et al. (2011) <doi:10.1289/ehp.1002476> and Sedykh A (2016) <doi:10.1007/978-1-4939-6346-1_14>). Other parametric fitting approaches (e.g., Hill equation) are also adopted for ease of comparison. 3-parameter Hill equation from 'tcpl' package (Filer D et al., <doi:10.1093/bioinformatics/btw680>) and 4-parameter Hill equation from Curve Class2 approach (Wang Y et al., <doi:10.2174/1875397301004010057>) are available. Also, methods for calculating the confidence interval around the activity metrics are also provided. The methods are based on the bootstrap approach to simulate the datasets (Hsieh J-H et al. <doi:10.1093/toxsci/kfy258>). The simulated datasets can be used to derive the baseline noise threshold in an assay endpoint. This threshold is critical in the toxicological studies to derive the point-of-departure (POD).
Version: | 1.3.1 |
Depends: | R (≥ 3.5) |
Imports: | dplyr (≥ 1.0.0), tibble, magrittr, tidyselect, boot, tidyr, purrr, rlang, stringr, ggplot2, Rdpack, methods, rJava, furrr |
Suggests: | testthat, knitr, rmarkdown, tcpl, future |
Published: | 2024-01-09 |
DOI: | 10.32614/CRAN.package.Rcurvep |
Author: | Jui-Hua Hsieh |
Maintainer: | Jui-Hua Hsieh <juihua.hsieh at gmail.com> |
BugReports: | https://github.com/moggces/Rcurvep/issues |
License: | MIT + file LICENSE |
URL: | https://github.com/moggces/Rcurvep |
NeedsCompilation: | no |
SystemRequirements: | Java |
Language: | en-US |
Materials: | README NEWS |
CRAN checks: | Rcurvep results |
Reference manual: | Rcurvep.pdf |
Vignettes: |
Parallel Computing Examples Using Rcurvep Practical applications using Rcurvep package |
Package source: | Rcurvep_1.3.1.tar.gz |
Windows binaries: | r-devel: Rcurvep_1.3.1.zip, r-release: Rcurvep_1.3.1.zip, r-oldrel: Rcurvep_1.3.1.zip |
macOS binaries: | r-release (arm64): Rcurvep_1.3.1.tgz, r-oldrel (arm64): Rcurvep_1.3.1.tgz, r-release (x86_64): Rcurvep_1.3.1.tgz, r-oldrel (x86_64): Rcurvep_1.3.1.tgz |
Old sources: | Rcurvep archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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