ParCC Tutorial Index

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ParCC Vignette Library

ParCC (Parameter Converter & Calculator) provides a comprehensive set of tutorials organized by topic. Each vignette includes realistic clinical scenarios, worked examples with R code, and references to the underlying methodology.

Getting Started

vignette("getting-started") – Installation, launching the app, and the Lab Notebook workflow

Core Conversions

vignette("core-conversions") – Rate to Probability, Odds to Probability, and Time Rescaling with real-world examples from the RE-LY trial and UKPDS Risk Engine

Hazard Ratio Conversion (NEW in v1.3.0)

vignette("hr-probability-converter") – Converting control group probabilities to intervention probabilities using Hazard Ratios. Includes worked examples from the PLATO trial (Ticagrelor vs Aspirin) and oncology models.

Survival Extrapolation

vignette("survival-extrapolation") – Fitting Exponential and Weibull survival curves from published Kaplan-Meier data when IPD is unavailable

Background Mortality

vignette("background-mortality") – SMR adjustment, DEALE, Gompertz parameterization, and linear interpolation for adjusting census life tables to disease-specific cohorts

Probabilistic Sensitivity Analysis

vignette("psa-distributions") – Fitting Beta (utilities), Gamma (costs), and LogNormal (HRs) distributions using the Method of Moments. Includes the Rule of 4 approximation.

Economic Evaluation

vignette("economic-evaluation") – ICER calculation, Net Monetary Benefit, and Value-Based Pricing (Headroom Analysis) with Indian HTA context

Batch Processing

vignette("batch-workflow") – Uploading CSV files for bulk conversion, including the new HR-based batch conversion

Key References

Sonnenberg FA, Beck JR. Markov models in medical decision making. Med Decis Making. 1993;13(4):322-338.
Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation. Oxford University Press; 2006.
Collett D. Modelling Survival Data in Medical Research. 3rd ed. Chapman and Hall/CRC; 2015.
Drummond MF, et al. Methods for the Economic Evaluation of Health Care Programmes. 4th ed. Oxford University Press; 2015.
Cosh E, et al. The value of ‘innovation headroom’. Value in Health. 2007;10(4):312-315.
NICE DSU. Technical Support Document 14: Survival analysis for economic evaluations. 2013.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.