| Type: | Package |
| Title: | PTE and RP for Optimally-Transformed Surrogate |
| Version: | 1.0 |
| Description: | Evaluates the strength of a surrogate marker by estimating the proportion of treatment effect explained (PTE) and relative power(RP) for the optimally-transformed version of the surrogate. Details available in Wang et al (2022) <doi:10.48550/arXiv.2209.08414>. |
| License: | GPL-2 | GPL-3 [expanded from: GPL] |
| Imports: | MASS, mvtnorm, stats, survival |
| NeedsCompilation: | no |
| Packaged: | 2022-10-10 10:55:29 UTC; parastlm |
| Author: | Layla Parast [cre], Xuan Wang [aut] |
| Maintainer: | Layla Parast <parast@austin.utexas.edu> |
| Depends: | R (≥ 3.5.0) |
| Repository: | CRAN |
| Date/Publication: | 2022-10-10 17:10:02 UTC |
Estimates PTE and RE
Description
Evaluates the strength of a surrogate marker by estimating the proportion of treatment effect explained (PTE) and relative power(RP) for the optimally-transformed version of the surrogate.
Usage
PTERP(data,ncut=c(50,100,150,200,500,1000),n.resam=500)
Arguments
data |
data |
ncut |
relative power is calculated at a specific sample size n; this is a numeric vector of sample sizes for which the user wants the relative power, default is c(50,100,150,200,500,1000) |
n.resam |
number of times to resample, default is 500 |
Value
A list of:
ptenew.es |
Proportion of treatment effect estimate |
rp_i1 |
Estimate of relative power at n=i1 where i1 is the first value given in ncut |
rp_i2 |
Estimate of relative power at n=i2 where i2 is the second value given in ncut, etc. |
pte.se |
Standard error estimate for the proportion of treatment effect explained |
rp.se.i1 |
Standard error estimate for the relative power at n=i1 where i1 is the first value given in ncut |
rp.se.i2 |
Standard error estimate for the relative power at n=i2 where i2 is the first value given in ncut, etc. |
Author(s)
Xuan Wang
Examples
data(exampledata)
output=PTERP(exampledata,ncut=c(50,100,150,200,500,1000))
#reduce resampling
output=PTERP(exampledata,ncut=c(50,100,150,200,500,1000),n.resam=5)
Hypothetical data for example
Description
Hypothetical data for example
Usage
data("exampledata")Format
- yob
the primary outcome
- sob
the surrogate marker
- aob
the treatment group indicator where 1 is treatment and 0 is control
Examples
data(exampledata)