PANACEA: Personalized Network-Based Anti-Cancer Therapy Evaluation

Identification of the most appropriate pharmacotherapy for each patient based on genomic alterations is a major challenge in personalized oncology. 'PANACEA' is a collection of personalized anti-cancer drug prioritization approaches utilizing network methods. The methods utilize personalized "driverness" scores from 'driveR' to rank drugs, mapping these onto a protein-protein interaction network. The "distance-based" method scores each drug based on these scores and distances between drugs and genes to rank given drugs. The "RWR" method propagates these scores via a random-walk with restart framework to rank the drugs. The methods are described in detail in Ulgen E, Ozisik O, Sezerman OU. 2023. PANACEA: network-based methods for pharmacotherapy prioritization in personalized oncology. Bioinformatics <doi:10.1093/bioinformatics/btad022>.

Version:	1.0.1
Depends:	R (≥ 4.0)
Imports:	org.Hs.eg.db, DBI, igraph, reshape2
Suggests:	rmarkdown, knitr, testthat (≥ 3.0.0), covr
Published:	2023-08-19
DOI:	10.32614/CRAN.package.PANACEA
Author:	Ege Ulgen [aut, cre, cph]
Maintainer:	Ege Ulgen <egeulgen at gmail.com>
BugReports:	https://github.com/egeulgen/PANACEA/issues
License:	MIT + file LICENSE
URL:	https://github.com/egeulgen/PANACEA, https://egeulgen.github.io/PANACEA/
NeedsCompilation:	yes
Citation:	PANACEA citation info
Materials:	README NEWS
CRAN checks:	PANACEA results

Documentation:

Reference manual:	PANACEA.pdf
Vignettes:	How to use PANACEA

Downloads:

Package source:	PANACEA_1.0.1.tar.gz
Windows binaries:	r-devel: PANACEA_1.0.1.zip, r-release: PANACEA_1.0.1.zip, r-oldrel: PANACEA_1.0.1.zip
macOS binaries:	r-release (arm64): PANACEA_1.0.1.tgz, r-oldrel (arm64): PANACEA_1.0.1.tgz, r-release (x86_64): PANACEA_1.0.1.tgz, r-oldrel (x86_64): PANACEA_1.0.1.tgz
Old sources:	PANACEA archive

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