The hardware and bandwidth for this mirror is donated by dogado GmbH, the Webhosting and Full Service-Cloud Provider. Check out our Wordpress Tutorial.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]dogado.de.
Karen: Kalman Reaction Networks
This is a stochastic framework that combines biochemical reaction networks with extended Kalman filter and Rauch-Tung-Striebel smoothing.
This framework allows to investigate the dynamics of cell differentiation from high-dimensional clonal tracking data subject to measurement noise, false negative errors, and systematically unobserved cell types.
Our tool can provide statistical support to biologists in gene therapy clonal tracking studies for a deeper understanding of clonal reconstitution dynamics. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.07.08.499353>.
| Version: |
1.0 |
| Depends: |
R (≥ 2.10) |
| Imports: |
Matrix, parallel, gaussquad, splines, scales, mvtnorm, tmvtnorm, MASS, igraph, xtable, stringr, abind, expm, methods |
| Suggests: |
R.rsp |
| Published: |
2022-09-15 |
| DOI: |
10.32614/CRAN.package.Karen |
| Author: |
Luca Del Core 
[aut, cre, cph],
Danilo Pellin
[aut],
Marco Grzegorczyk
[aut, ths],
Ernst Wit [aut,
ths] |
| Maintainer: |
Luca Del Core <l.del.core at rug.nl> |
| License: |
GPL-3 |
| NeedsCompilation: |
no |
| CRAN checks: |
Karen results |
Documentation:
Downloads:
Linking:
Please use the canonical form
https://CRAN.R-project.org/package=Karen
to link to this page.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
Health stats visible at Monitor.