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The HIMA function is described in:

Zhang H, Zheng Y, Zhang Z, Gao T, Joyce B, Yoon G, Zhang W, Schwartz J, Just A, Colicino E, Vokonas P, Zhao L, Lv J, Baccarelli A, Hou L, Liu L (2016). “Estimating and Testing High-dimensional Mediation Effects in Epigenetic Studies.” Bioinformatics, 32(20), 3150-3154. doi:10.1093/bioinformatics/btw351.

The survHIMA function is described in:

Zhang H, Zheng Y, Hou L, Liu L (2021). “Mediation Analysis for Survival Data with High-Dimensional Mediators.” Bioinformatics, 37(21), 3815-3821. doi:10.1093/bioinformatics/btab564.

The microHIMA function is described in:

Zhang H, Chen J, Feng Y, Wang C, Li H, Liu L (2021). “Mediation Analysis for Survival Data with High-Dimensional Mediators.” Statistics in medicine, 40(4), 885-896. doi:10.1002/sim.8808.

Corresponding BibTeX entries:

  @Article{HIMA,
    title = {{Estimating and Testing High-dimensional Mediation Effects
      in Epigenetic Studies}},
    author = {Haixiang Zhang and Yinan Zheng and Zhou Zhang and Tao Gao
      and Brian Joyce and Grace Yoon and Wei Zhang and Joel Schwartz
      and Allan Just and Elena Colicino and Pantel Vokonas and Lihui
      Zhao and Jinchi Lv and Andrea Baccarelli and Lifang Hou and Lei
      Liu},
    journal = {Bioinformatics},
    year = {2016},
    volume = {32},
    number = {20},
    pages = {3150-3154},
    doi = {10.1093/bioinformatics/btw351},
    pubmed = {27357171},
  }
  @Article{survHIMA,
    title = {{Mediation Analysis for Survival Data with
      High-Dimensional Mediators}},
    author = {Haixiang Zhang and Yinan Zheng and Lifang Hou and Lei
      Liu},
    journal = {Bioinformatics},
    year = {2021},
    volume = {37},
    number = {21},
    pages = {3815-3821},
    doi = {10.1093/bioinformatics/btab564},
    pubmed = {34343267},
  }
  @Article{microHIMA,
    title = {{Mediation Analysis for Survival Data with
      High-Dimensional Mediators}},
    author = {Haixiang Zhang and Jun Chen and Yang Feng and Chan Wang
      and Huilin Li and Lei Liu},
    journal = {Statistics in medicine},
    year = {2021},
    volume = {40},
    number = {4},
    pages = {885-896},
    doi = {10.1002/sim.8808},
    pubmed = {33205470},
  }

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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