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A systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. 'DrugSim2DR' first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.
| Version: | 0.1.1 |
| Depends: | R (≥ 3.6) |
| Imports: | igraph, stats, pheatmap, ChemmineR, rvest, base, sp, tidyr, reshape2, fastmatch |
| Suggests: | knitr, rmarkdown |
| Published: | 2023-08-10 |
| DOI: | 10.32614/CRAN.package.DrugSim2DR |
| Author: | Junwei Han [aut, cre, cph], Ji Li [aut], Jiashuo Wu [aut] |
| Maintainer: | Junwei Han <hanjunwei1981 at 163.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | DrugSim2DR results |
| Reference manual: | DrugSim2DR.pdf |
| Vignettes: |
DrugSim2DR User Guide |
| Package source: | DrugSim2DR_0.1.1.tar.gz |
| Windows binaries: | r-devel: DrugSim2DR_0.1.1.zip, r-release: DrugSim2DR_0.1.1.zip, r-oldrel: DrugSim2DR_0.1.1.zip |
| macOS binaries: | r-release (arm64): DrugSim2DR_0.1.1.tgz, r-oldrel (arm64): DrugSim2DR_0.1.1.tgz, r-release (x86_64): DrugSim2DR_0.1.1.tgz, r-oldrel (x86_64): DrugSim2DR_0.1.1.tgz |
| Old sources: | DrugSim2DR archive |
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