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DEHOGT: Differentially Expressed Heterogeneous Overdispersion Gene Test
for Count Data
Implements a generalized linear model approach for detecting
differentially expressed genes across treatment groups in count data. The
package supports both quasi-Poisson and negative binomial models to handle
over-dispersion, ensuring robust identification of differential expression.
It allows for the inclusion of treatment effects and gene-wise covariates,
as well as normalization factors for accurate scaling across samples.
Additionally, it incorporates statistical significance testing with
options for p-value adjustment and log2 fold range thresholds,
making it suitable for RNA-seq analysis as described in by
Xu et al., (2024) <doi:10.1371/journal.pone.0300565>.
Documentation:
Downloads:
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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[cre],
Yubai Yuan [ctb],
Annie Qu [ctb]