0. Overview of the package

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0. Analysis workflow & supported model types

Analysis can be performed in the following simple steps.

Figure: Overall analysis workflow

Supported model types are as follows:

	Binary endpoint		Continuous endpoint
	Linear (logit)	Emax (logit)	Linear	Emax
backend	`rstanarm`	`rstanemax`	`rstanarm`	`rstanemax`
reference	🔗	🔗	🔗	🔗
develop model	✅	✅	✅	✅
simulate & plot ER	✅	✅	✅	✅
exposure metrics selection	✅	✅	✅	✅
covariate selection	✅	❌	✅	❌
covariate forest plot	✅	❌	🟡	❌
✅ Available, 🟡 In plan/under development, ❌ Not in a current plan

1. ER model development

The package provides a set of functions to develop ER models. The following functions are available:

Binary endpoint, linear logistic regression: dev_ermod_bin(), dev_ermod_bin_exp_sel(), dev_ermod_bin_cov_sel()
Continuous endpoint, Emax: dev_ermod_emax()

Figure: dev_ermod_*() functions

2. Simulation from developed ER model

The following functions are available for simulation from developed ER models:

sim_er()
sim_er_new_exp(), sim_er_curve()
sim_er_new_exp_marg(), sim_er_curve_marg()

Figure: sim_er_*() functions

3. Plot simulated ER curve

Simulated ER curve can be visualized with the following functions:

plot_er()
plot_er_exp_sel()

Figure: plot_er_*() functions

Acknowledgement

Figure created in https://www.biorender.com

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.
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