ActiveDriverWGS: A Driver Discovery Tool for Cancer Whole Genomes

A method for finding enrichments of somatic single nucleotide variants (SNVs) and small insertions-deletions (Indels) in functional elements in the human genome. 'ActiveDriverWGS' detects coding and noncoding cancer driver elements using whole genome sequencing data. The method is part of the publication H. Zhu et al. (2020) <doi:10.1016/j.molcel.2019.12.027> "Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks" in Molecular Cell.

Version:	1.2.1
Depends:	R (≥ 3.5)
Imports:	BSgenome, Biostrings, GenomeInfoDb, GenomicRanges, IRanges, S4Vectors
Suggests:	BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm9, BSgenome.Mmusculus.UCSC.mm10, knitr, testthat, rmarkdown
Published:	2026-03-13
DOI:	10.32614/CRAN.package.ActiveDriverWGS
Author:	Juri Reimand [aut, cre], Helen Zhu [ctb], Kevin Cheng [ctb]
Maintainer:	Juri Reimand <juri.reimand at utoronto.ca>
License:	GPL-3
NeedsCompilation:	no
Materials:	README, NEWS
CRAN checks:	ActiveDriverWGS results

Documentation:

Reference manual:	ActiveDriverWGS.html , ActiveDriverWGS.pdf
Vignettes:	ActiveDriverWGS (source, R code)

Downloads:

Package source:	ActiveDriverWGS_1.2.1.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): ActiveDriverWGS_1.2.1.tgz, r-oldrel (arm64): ActiveDriverWGS_1.2.1.tgz, r-release (x86_64): ActiveDriverWGS_1.2.1.tgz, r-oldrel (x86_64): not available
Old sources:	ActiveDriverWGS archive

Linking:

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