Calculates maximum likelihood estimate, exact and asymptotic confidence intervals, and exact and asymptotic goodness of fit p-values for concentration of infectious units from serial limiting dilution assays. This package uses the likelihood equation, exact goodness of fit p-values, and exact confidence intervals described in Meyers et al. (1994) <http://jcm.asm.org/content/32/3/732.full.pdf>. This software is also implemented as a web application through the Shiny R package <https://iupm.shinyapps.io/sldassay/>.

Compute Time series Resistant Smooth 4253H, twice smoothing method.

Sleep cycles are largely detected according to the originally proposed criteria by Feinberg & Floyd (1979) <doi:10.1111/j.1469-8986.1979.tb02991.x> as described in Blume & Cajochen (2021) <doi:10.1016/j.mex.2021.101318>.

For those wishing to interact with the 'Sleeper' (Fantasy Sports) API (<https://docs.sleeper.com/>) without looking too much into its documentation (found at <https://docs.sleeper.com/>), this package offers wrapper functions around the available API calls to make it easier.

Use behavioural variables to score activity and infer sleep from bouts of immobility. 
    It is primarily designed to score sleep in fruit flies from Drosophila Activity Monitor (TriKinetics) and Ethoscope data.
    It implements sleep scoring using the "five-minute rule" (Hendricks et al. (2000) <DOI:10.1016/S0896-6273(00)80877-6>),
    activity classification for Ethoscopes (Geissmann et al. (2017) <DOI:10.1371/journal.pbio.2003026>) 
    and a new algorithm to detect when animals are dead.

A tool to interactively explore the
  embeddings created by dimension reduction methods such as 
  Principal Components Analysis (PCA), Multidimensional Scaling (MDS), 
  T-distributed Stochastic Neighbour Embedding (t-SNE),
  Uniform Manifold Approximation and Projection (UMAP) or any other.

Efficient regression analysis under general two-phase sampling, where Phase I includes error-prone data and Phase II contains validated data on a subset.