Aggregates multiple Receiver Operating Characteristic (ROC) curves 
    obtained from different sources into one global ROC. Additionally, it’s 
    also possible to calculate the aggregated precision-recall (PR) curve.

Generation of Box-Cox based ROC curves and several aspects of inferences and hypothesis testing. Can be used when inferences for one biomarker (Bantis LE, Nakas CT, Reiser B. (2018)<doi:10.1002/bimj.201700107>) are of interest or when comparisons of two correlated biomarkers (Bantis LE, Nakas CT, Reiser B. (2021)<doi:10.1002/bimj.202000128>) are of interest. Provides inferences and comparisons around the AUC, the Youden index, the sensitivity at a given specificity level (and vice versa), the optimal operating point of the ROC curve (in the Youden sense), and the Youden based cutoff.

Functions for a classification method based on receiver operating characteristics (ROC). Briefly, features are selected according to their ranked AUC value in the training set. The selected features are merged by the mean value to form a meta-gene. The samples are ranked by their meta-gene value and the meta-gene threshold that has the highest accuracy in splitting the training samples is determined. A new sample is classified by its meta-gene value relative to the threshold. In the first place, the package is aimed at two class problems in gene expression data, but might also apply to other problems.

Cross validate large genetic data while specifying clinical variables that should always be in the model using the function cv(). An ROC plot from the cross validation data with AUC can be obtained using rocplot(), which also can be used to compare different models. Framework was built to handle genetic data, but works for any data.

The algorithm provided in this package generates perfect sample for unimodal or multimodal posteriors. Read Once Coupling From The Past, with Metropolis-Multishift is used to generate a perfect sample for a given posterior density based on the two extreme starting paths, minimum and maximum of the most interest range of the posterior. It uses the monotone random operation of multishift coupler which allows to sandwich all of the state space in one point. It means both Markov Chains starting from the maximum and minimum will be coalesced. The generated sample is independent from the starting points. It is useful for mixture distributions too. The output of this function is a real value as an exact draw from the posterior distribution.