Provides access to the complete Pali Canon, or
    Tipitaka, the canonical scripture for Theravadin Buddhists 
    worldwide. Based on the Chattha Sangayana Tipitaka version
    4 (Vipassana Research Institute, 1990).

Tipping point analysis for clinical trials that employ Bayesian dynamic borrowing via robust meta-analytic predictive (MAP) priors. Further functions facilitate expert elicitation of a primary weight of the informative component of the robust MAP prior and computation of operating characteristics. Intended use is the planning, analysis and interpretation of extrapolation studies in pediatric drug development, but applicability is generally wider.

'Htmlwidget' of 'Tippyjs' to add tooltips to 'Shiny' apps and 'R markdown' documents.

The strength of evidence provided by epidemiological and
    observational studies is inherently limited by the potential for
    unmeasured confounding.  We focus on three key quantities: the
    observed bound of the confidence interval closest to the null, the
    relationship between an unmeasured confounder and the outcome, for
    example a plausible residual effect size for an unmeasured continuous
    or binary confounder, and the relationship between an unmeasured
    confounder and the exposure, for example a realistic mean difference
    or prevalence difference for this hypothetical confounder between
    exposure groups. Building on the methods put forth by Cornfield et al.
    (1959), Bross (1966), Schlesselman (1978), Rosenbaum & Rubin (1983),
    Lin et al. (1998), Lash et al. (2009), Rosenbaum (1986), Cinelli &
    Hazlett (2020), VanderWeele & Ding (2017), and Ding & VanderWeele
    (2016), we can use these quantities to assess how an unmeasured
    confounder may tip our result to insignificance.

Generates stochastic time series and genealogies associated with a population dynamics model. Times series are simulated using the Gillespie exact and approximate algorithms and a new algorithm we introduce that uses both approaches to optimize the time execution of the simulations. Genealogies are simulated from a trajectory using a backwards-in-time based approach. Methods are described in Danesh G et al (2022) <doi:10.1111/2041-210X.14038>.