Implementation of the technique of Lleonart et al. 
    (2000) <doi:10.1006/jtbi.2000.2043> to scale body measurements 
    that exhibit an allometric growth. This procedure is a theoretical 
    generalization of the technique used by Thorpe 
    (1975) <doi:10.1111/j.1095-8312.1975.tb00732.x> and
    Thorpe (1976) <doi:10.1111/j.1469-185X.1976.tb01063.x>.

We developed a lightweight machine learning tool for RNA profiling of acute lymphoblastic leukemia (ALL), however, it can be used for any problem where multiple classes need to be identified from multi-dimensional data. The methodology is described in Makinen V-P, Rehn J, Breen J, Yeung D, White DL (2022) Multi-cohort transcriptomic subtyping of B-cell acute lymphoblastic leukemia, International Journal of Molecular Sciences 23:4574, <doi:10.3390/ijms23094574>. The classifier contains optimized mean profiles of the classes (centroids) as observed in the training data, and new samples are matched to these centroids using the shortest Euclidean distance. Centroids derived from a dataset of 1,598 ALL patients are included, but users can train the models with their own data as well. The output includes both numerical and visual presentations of the classification results. Samples with mixed features from multiple classes or atypical values are also identified.

Provides statistical tools to analyze heterogeneous effects of rare variants within genes that are associated with multiple traits. The package implements methods for assessing pleiotropic effects and identifying allelic heterogeneity, which can be useful in large-scale genetic studies. Methods include likelihood-based statistical tests to assess these effects. For more details, see Lu et al. (2024) <doi:10.1101/2024.10.01.614806>.

Creating alluvial diagrams (also known as parallel sets plots) for multivariate
  and time series-like data.

Provides tools for defining recurrence rules and recurrence
    sets. Recurrence rules are a programmatic way to define a recurring
    event, like the first Monday of December. Multiple recurrence rules
    can be combined into larger recurrence sets. A full holiday and
    calendar interface is also provided that can generate holidays within
    a particular year, can detect if a date is a holiday, can respect
    holiday observance rules, and allows for custom holidays.