Given vectors of family sizes and number of affecteds per family, calculates the risk of disease recurrence in an unaffected person, conditional on a family having at least k affected members. Methods also model heterogeneity of disease risk across families by fitting a mixture model, allowing for high and low risk families.

Fatty acid metabolic analysis aimed to the estimation of FA import (I), de novo synthesis (S), fractional contribution of the 13C-tracers (D0, D1, D2), elongation (E) and desaturation (Des) based on mass isotopologue data.

Simulates age-at-onset traits associated with a segregating major gene in family data 
     obtained from population-based, clinic-based, or multi-stage designs. Appropriate ascertainment 
     correction is utilized to estimate age-dependent penetrance functions either parametrically from 
     the fitted model or nonparametrically from the data. The Expectation and Maximization algorithm 
     can infer missing genotypes and carrier probabilities estimated from family's genotype and
     phenotype information or from a fitted model. Plot functions include pedigrees of simulated 
     families and predicted penetrance curves based on specified parameter values.
     For more information see Choi, Y.-H., Briollais, L., He, W. and Kopciuk, K. (2021) FamEvent: An 
     R Package for Generating and Modeling Time-to-Event Data in Family Designs, 
     Journal of Statistical Software 97 (7), 1-30.

Provides functionality for testing familial hypotheses. Supports testing centers 
    belonging to the Huber family. Testing is carried out using the Bayesian bootstrap. One- and 
    two-sample tests are supported, as are directional tests. Methods for visualizing output are 
    provided.

Single unified interface for end-to-end modelling of regression, 
    categorical and time-to-event (survival) outcomes. Models created using
    familiar are self-containing, and their use does not require additional
    information such as baseline survival, feature clustering, or feature
    transformation and normalisation parameters. Model performance,
    calibration, risk group stratification, (permutation) variable importance,
    individual conditional expectation, partial dependence, and more, are
    assessed automatically as part of the evaluation process and exported in
    tabular format and plotted, and may also be computed manually using export
    and plot functions. Where possible, metrics and values obtained during the
    evaluation process come with confidence intervals.