Utility functions to facilitate the import, 
 the reporting and analysis of clinical data.
 Example datasets in 'SDTM' and 'ADaM' format, containing a subset of patients/domains
 from the 'CDISC Pilot 01 study' are also available as R datasets to demonstrate
 the package functionalities.

Collection of indices and tools relating to cardiovascular, nephrology, and hepatic research that aid epidemiological chort or retrospective chart review with big data. All indices and tools take commonly used lab values and patient demographics and measurements to compute various risk and predictive values for survival. References to original literature and validation contained in each function documentation.

A fast and general implementation of the Elston-Stewart algorithm
 that can calculate the likelihoods of large and complex pedigrees. 
 References for the Elston-Stewart algorithm are
 Elston & Stewart (1971) <doi:10.1159/000152448>,
 Lange & Elston (1975) <doi:10.1159/000152714> and
 Cannings et al. (1978) <doi:10.2307/1426718>.

Simple utility functions to read from and write to
    the Windows, OS X, and X11 clipboards.

Clique percolation community detection for weighted and
    unweighted networks as well as threshold and plotting functions.
    For more information see Farkas et al. (2007) <doi:10.1088/1367-2630/9/6/180>
    and Palla et al. (2005) <doi:10.1038/nature03607>.

A small subset of Unicode symbols, that are useful
    when building command line applications. They fall back to
    alternatives on terminals that do not support Unicode.
    Many symbols were taken from the 'figures' 'npm' package
    (see <https://github.com/sindresorhus/figures>).

Estimation and inference for linear models where some or all of the
    fixed-effects coefficients are subject to order restrictions. This package uses
    the robust residual bootstrap methodology for inference, and can handle some
    structure in the residual variance matrix.

Implementation of the age-period-cohort models for the claim development presented in the manuscript 'Replicating and extending chain-ladder via an age-period-cohort structure on the claim development in a run-off triangle' <doi:10.48550/arXiv.2301.03858>.