Encrypts and decrypts strings using either the Caesar cipher or a
    pseudorandom number generation (using set.seed()) method.

Biotechnology in spatial omics has advanced rapidly over the past few years, enhancing both throughput and resolution. However, existing annotation pipelines in spatial omics predominantly rely on clustering methods, lacking the flexibility to integrate extensive annotated information from single-cell RNA sequencing (scRNA-seq) due to discrepancies in spatial resolutions, species, or modalities. Here we introduce the CAESAR suite, an open-source software package that provides image-based spatial co-embedding of locations and genomic features. It uniquely transfers labels from scRNA-seq reference, enabling the annotation of spatial omics datasets across different technologies, resolutions, species, and modalities, based on the conserved relationship between signature genes and cells/locations at an appropriate level of granularity. Notably, CAESAR enriches location-level pathways, allowing for the detection of gradual biological pathway activation within spatially defined domain types. More details on the methods related to our paper currently under submission. A full reference to the paper will be provided in future versions once the paper is published.

Simulate plasma caffeine concentrations using population pharmacokinetic model described in Lee, Kim, Perera, McLachlan and Bae (2015) <doi:10.1007/s00431-015-2581-x>.

A time series usually does not have a uniform growth rate. Compound Annual Growth Rate measures the average annual growth over a given period. More details can be found in Bardhan et al. (2022) <DOI:10.18805/ag.D-5418>.

Provides functions for the estimation of the conditional Akaike
    information in generalized mixed-effect models fitted with (g)lmer() 
    from 'lme4', lme() from 'nlme' and gamm() from 'mgcv'.
    For a manual on how to use 'cAIC4', see Saefken et al. (2021) <doi:10.18637/jss.v099.i08>.

Allows to plot a number of information related to the interpretation of Correspondence Analysis' results. It provides the facility to plot the contribution of rows and columns categories to the principal dimensions, the quality of points display on selected dimensions, the correlation of row and column categories to selected dimensions, etc. It also allows to assess which dimension(s) is important for the data structure interpretation by means of different statistics and tests. The package also offers the facility to plot the permuted distribution of the table total inertia as well as of the inertia accounted for by pairs of selected dimensions. Different facilities are also provided that aim to produce interpretation-oriented scatterplots. Reference: Alberti 2015 <doi:10.1016/j.softx.2015.07.001>.