A system for binary and multi-class classification of
    high-dimensional phenotypic data using ensemble learning. By combining
    predictions from different classification models, this package attempts
    to improve performance over individual learners. The pre-processing,
    training, validation, and testing are performed end-to-end to minimize
    user input and simplify the process of classification.

Implement surrogate-assisted feature extraction (SAFE) and
             common machine learning approaches to train and validate phenotyping models.
             Background and details about the methods can be found at 
             Zhang et al. (2019) <doi:10.1038/s41596-019-0227-6>,
             Yu et al. (2017) <doi:10.1093/jamia/ocw135>, and 
             Liao et al. (2015) <doi:10.1136/bmj.h1885>.

To build a shiny app for visualization of the hierarchy of PheCode Mapping with International Classification of Diseases (ICD). The same PheCode hierarchy is displayed in two ways: as a sunburst plot and as a tree.

Functions to calculate commonly used public health statistics and 
    their confidence intervals using methods approved for use in the production  
    of Public Health England indicators such as those presented via Fingertips 
    (<http://fingertips.phe.org.uk/>). It provides functions for the generation 
    of proportions, crude rates, means, directly standardised rates, indirectly 
    standardised rates, standardised mortality ratios, slope and relative index
    of inequality and life expectancy. 
    Statistical methods are referenced in the following publications. 
    Breslow NE, Day NE (1987) <doi:10.1002/sim.4780080614>.
    Dobson et al (1991) <doi:10.1002/sim.4780100317>. 
    Armitage P, Berry G (2002) <doi:10.1002/9780470773666>.
    Wilson EB. (1927) <doi:10.1080/01621459.1927.10502953>.
    Altman DG et al (2000, ISBN: 978-0-727-91375-3).
    Chiang CL. (1968, ISBN: 978-0-882-75200-6).
    Newell C. (1994, ISBN: 978-0-898-62451-9).
    Eayres DP, Williams ES (2004) <doi:10.1136/jech.2003.009654>.
    Silcocks PBS et al (2001) <doi:10.1136/jech.55.1.38>.
    Low and Low (2004) <doi:10.1093/pubmed/fdh175>.