A systematic bioinformatics tool to develop a new pathway-based gene panel for tumor mutational burden (TMB) assessment (pathway-based tumor mutational burden, PTMB), using somatic mutations files in an efficient manner from either The Cancer Genome Atlas sources or any in-house studies as long as the data is in mutation annotation file (MAF) format. Besides, we develop a multiple machine learning method using the sample's PTMB profiles to identify cancer-specific dysfunction pathways, which can be a biomarker of prognostic and predictive for cancer immunotherapy.

Identify the characteristics of patients in data mapped to the Observational Medical Outcomes Partnership (OMOP) common data model.

Creation of patient profile visualizations for
  exploration, diagnostic or monitoring purposes during a clinical trial.
  These static visualizations display a patient-specific overview
  of the evolution during the trial time frame of 
  parameters of interest (as laboratory, ECG, vital signs),
  presence of adverse events, exposure to a treatment; 
  associated with metadata patient information, 
  as demography, concomitant medication.
  The visualizations can be tailored for specific domain(s) or endpoint(s) of interest.
  Visualizations are exported into patient profile report(s)
  or can be embedded in custom report(s).

This is an extension of the 'testthat' package that
    lets you add parameters to your unit tests. Parameterized unit tests
    are often easier to read and more reliable, since they follow the DNRY
    (do not repeat yourself) rule.

Provides a set of functions to efficiently recognize and clean the continuous dorsal pattern of a female brown anole lizard (Anolis sagrei) traced from 'ImageJ', an open platform for scientific image analysis (see <https://imagej.net> for more information), and extract common features such as the pattern sinuosity indices, coefficient of variation, and max-min width.

The model proposes a robust methodology for detecting and reconstructing the hidden structure of dynamic complex systems through short-term forecasts and information embedded in reconstructed state spaces. The approach not only identifies critical components and causal interactions within these systems but also provides a practical tool for optimizing system performance and stability.