An interface between R and the 'OSRM' API. 'OSRM' is a routing
    service based on 'OpenStreetMap' data. See <http://project-osrm.org/> for more
    information. This package enables the computation of routes, trips, isochrones and
    travel distances matrices (travel time and kilometric distance).

Wrapper around the 'Open Source Routing Machine (OSRM)'
        API <http://project-osrm.org/>. 'osrmr' works with API versions
        4 and 5 and can handle servers that run locally as well as the
        'OSRM' webserver.

A system for calculating the minimum total sample size needed to achieve a prespecified power or the optimal allocation for each treatment group with a fixed total sample size to maximize the power.

Identifies the optimal transformation of a surrogate marker and estimates the proportion of treatment explained (PTE) by the optimally-transformed surrogate at an earlier time point when the primary outcome of interest is a censored time-to-event outcome; details are described in Wang et al (2021) <doi:10.1002/sim.9185>.

O-statistics, or overlap statistics, measure the degree of community-level trait overlap. 
    They are estimated by fitting nonparametric kernel density functions to each species’ trait 
    distribution and calculating their areas of overlap. For instance, the median pairwise overlap 
    for a community is calculated by first determining the overlap of each species pair 
    in trait space, and then taking the median overlap of each species pair in a community. 
    This median overlap value is called the O-statistic (O for overlap).
    The Ostats() function calculates separate univariate overlap statistics for each trait, 
    while the Ostats_multivariate() function calculates a single multivariate overlap statistic for all traits. 
    O-statistics can be evaluated against null models to obtain standardized effect sizes. 
    'Ostats' is part of the collaborative Macrosystems Biodiversity Project "Local- to continental-scale 
    drivers of biodiversity across the National Ecological Observatory Network (NEON)." 
    For more information on this project, see the Macrosystems Biodiversity Website 
    (<https://neon-biodiversity.github.io/>). Calculation of O-statistics is described in
    Read et al. (2018) <doi:10.1111/ecog.03641>, and a teaching module for introducing the
    underlying biological concepts at an undergraduate level is described in Grady et al.
    (2018) <http://tiee.esa.org/vol/v14/issues/figure_sets/grady/abstract.html>.