Implementation of target-controlled infusion algorithms for compartmental pharmacokinetic and pharmacokinetic-pharmacodynamic models. Jacobs (1990) <doi:10.1109/10.43622>; Marsh et al. (1991) <doi:10.1093/bja/67.1.41>; Shafer and Gregg (1993) <doi:10.1007/BF01070999>; Schnider et al. (1998) <doi:10.1097/00000542-199805000-00006>; Abuhelwa, Foster, and Upton (2015) <doi:10.1016/j.vascn.2015.03.004>; Eleveld et al. (2018) <doi:10.1016/j.bja.2018.01.018>.

A wrapper for The Cancer Imaging Archive's REST API. The Cancer
    Imaging Archive (TCIA) hosts de-identified medical images of cancer
    available for public download, as well as rich metadata for each image
    series. TCIA provides a REST API for programmatic access to the data.
    This package provides simple functions to access each API endpoint.
    For more information, see <https://github.com/pamelarussell/TCIApathfinder>
    and TCIA's website.

Provide the core functionality to transform longitudinal data to
    complex-time (kime) data using analytic and numerical techniques, visualize the original 
    time-series and reconstructed kime-surfaces, perform model based (e.g., tensor-linear regression)
    and model-free classification and clustering methods in the book Dinov, ID and Velev, MV. (2021)
    "Data Science: Time Complexity, Inferential Uncertainty, and Spacekime Analytics", De Gruyter STEM Series,
    ISBN 978-3-11-069780-3. <https://www.degruyter.com/view/title/576646>.
    The package includes 18 core functions which can be separated into three groups.
    1) draw longitudinal data, such as Functional magnetic resonance imaging(fMRI) time-series, and forecast or transform the time-series data.
    2) simulate real-valued time-series data, e.g., fMRI time-courses, detect the activated areas,
    report the corresponding p-values, and visualize the p-values in the 3D brain space.
    3) Laplace transform and kimesurface reconstructions of the fMRI data.

An implementation of hypothesis testing in an extended Rasch modeling framework,
    including sample size planning procedures and power computations. Provides 4 statistical tests, 
    i.e., gradient test (GR), likelihood ratio test (LR), Rao score or Lagrange multiplier test (RS), 
    and Wald test, for testing a number of hypotheses referring to the Rasch model (RM), linear 
    logistic test model (LLTM), rating scale model (RSM), and partial credit model (PCM). Three 
    types of functions for power and sample size computations are provided. Firstly, functions to 
    compute the sample size given a user-specified (predetermined) deviation from the hypothesis 
    to be tested, the level alpha, and the power of the test. Secondly, functions to evaluate the 
    power of the tests given a user-specified (predetermined) deviation from the hypothesis to be 
    tested, the level alpha of the test, and the sample size. Thirdly, functions to evaluate the 
    so-called post hoc power of the tests. This is the power of the tests given the observed 
    deviation of the data from the hypothesis to be tested and a user-specified level alpha of the
    test. Power and sample size computations are based on a Monte Carlo simulation approach. It is
    computationally very efficient. The variance of the random error in computing power and sample
    size arising from the simulation approach is analytically derived by using the delta method. 
    Draxler, C., & Alexandrowicz, R. W. (2015), <doi:10.1007/s11336-015-9472-y>.