Implements Bayesian phase I repeated measurement design that 
    accounts for multidimensional toxicity endpoints and longitudinal efficacy 
    measure from multiple treatment cycles. The package provides flags to 
    fit a variety of model-based phase I design, including 1 stage models with
    or without individualized dose modification, 3-stage models with or without
    individualized dose modification, etc. Functions are provided to recommend 
    dosage selection based on the data collected in the available patient cohorts 
    and to simulate trial characteristics given design parameters. 
    Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Performs a qualitative analysis of one- and two-dimensional
   autonomous ordinary differential equation systems, using phase plane methods.
   Programs are available to identify and classify equilibrium points, plot the
   direction field, and plot trajectories for multiple initial conditions. In
   the one-dimensional case, a program is also available to plot the phase
   portrait. Whilst in the two-dimensional case, programs are additionally
   available to plot nullclines and stable/unstable manifolds of saddle points.
   Many example systems are provided for the user. For further details can be
   found in Grayling (2014) <doi:10.32614/RJ-2014-023>.

Functions to perform Bayesian inference on absorption time data for
             Phase-type distributions. The methods of Bladt et al (2003)
             <doi:10.1080/03461230110106435> and Aslett (2012)
             <https://www.louisaslett.com/PhD_Thesis.pdf> are provided.