For high-dimensional data whose main feature is a large number, p, of variables but a small sample size, the null hypothesis that the marginal distributions of p variables are the same for two groups is tested. We propose a test statistic motivated by the simple idea of comparing, for each of the p variables, the empirical characteristic functions computed from the two samples. If one rejects this global null hypothesis of no differences in distributions between the two groups, a set of permutation p-values is reported to identify which variables are not equally distributed in both groups.

Implements the TWO-Component Single Cell Model-Based Association Method (TWO-SIGMA) for gene-level differential expression (DE) analysis and DE-based gene set testing of single-cell RNA-sequencing datasets. See Van Buren et al. (2020) <doi:10.1002/gepi.22361> and Van Buren et al. (2021) <doi:10.1101/2021.01.24.427979>.

An inverse probability of censoring weighted (IPCW) targeted maximum likelihood estimator (TMLE) for evaluating a marginal point treatment effect from data where some variables were collected on only a subset of participants using a two-stage design (or marginal mean outcome for a single arm study). A TMLE for conditional parameters defined by a marginal structural model (MSM) is also available.

Conditional logistic regression with longitudinal follow up and
    individual-level random coefficients: A stable and efficient
    two-step estimation method.

Carries out analyses of two-way tables with one observation per cell, together with graphical displays
    for an additive fit and
    a diagnostic plot for removable 'non-additivity' via a power transformation of the response.
    It implements Tukey's Exploratory Data Analysis (1973) <ISBN: 978-0201076165> methods, including a
    1-degree-of-freedom test for row*column 'non-additivity', linear in the row and column effects.

Estimates the weights and measure of robustness to treatment effect heterogeneity attached to two-way fixed effects regressions.
    Clément de Chaisemartin, Xavier D'Haultfœuille (2020) <DOI: 10.1257/aer.20181169>.