Pharmacokinetics is the study of drug absorption, distribution, 
   metabolism, and excretion. The pharmacokinetics model explains that how the 
   drug concentration change as the drug moves through the different compartments
   of the body. For pharmacokinetic modeling and analysis, it is essential
   to understand the basic pharmacokinetic parameters. All parameters are 
   considered, but only some of parameters are used in the model. Therefore, 
   we need to convert the estimated parameters to the other parameters after 
   fitting the specific pharmacokinetic model. This package is developed to help
   this converting work. For more detailed explanation of pharmacokinetic 
   parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001";
   "Benet and Zia-Amirhosseini" (1995) <DOI: 10.1177/019262339502300203>; 
   "Mould and Upton" (2012) <DOI: 10.1038/psp.2012.4>;
   "Mould and Upton" (2013) <DOI: 10.1038/psp.2013.14>.

Prepare pharmacokinetic/pharmacodynamic (PK/PD) data for PK/PD analyses. 
    This package provides functions to standardize infusion and bolus dose data while
    linking it to drug level or concentration data.

Provides functions used to build R packages. Locates
    compilers needed to build R packages on various platforms and ensures
    the PATH is configured appropriately so R can use them.

Metadata and package cache for CRAN-like repositories.  This
    is a utility package to be used by package management tools that want
    to take advantage of caching.

This provides utilities for creating classed error and warning
  conditions based on where the error originated.

Set configuration options on a per-package basis.
    Options set by a given package only apply to that package,
    other packages are unaffected.

Find recursive dependencies of 'R' packages from various
    sources. Solve the dependencies to obtain a consistent set of packages
    to install. Download packages, and install them. It supports packages
    on 'CRAN', 'Bioconductor' and other 'CRAN-like' repositories,
    'GitHub', package 'URLs', and local package trees and files. It caches
    metadata and package files via the 'pkgcache' package, and performs
    all 'HTTP' requests, downloads, builds and installations in parallel.
    'pkgdepends' is the workhorse of the 'pak' package.