A light, simple tool for sending emails with minimal dependencies.

Variable selection methods have been extensively developed for analyzing highdimensional omics data within both the frequentist and Bayesian frameworks. This package provides implementations of the spike-and-slab quantile (group) LASSO which have been developed along the line of Bayesian hierarchical models but deeply rooted in frequentist regularization methods by utilizing Expectation–Maximization (EM) algorithm. The spike-and-slab quantile LASSO can handle data irregularity in terms of skewness and outliers in response variables, compared to its non-robust alternative, the spike-and-slab LASSO, which has also been implemented in the package. In addition, procedures for fitting the spike-and-slab quantile group LASSO and its non-robust counterpart have been implemented in the form of quantile/least-square varying coefficient mixed effect models for high-dimensional longitudinal data. The core module of this package is developed in 'C++'.

Unsupervised, multivariate, binary clustering for meaningful annotation of data, taking into account the uncertainty in the data. A specific constructor for trajectory analysis in movement ecology yields behavioural annotation of trajectories based on estimated local measures of velocity and turning angle, eventually with solar position covariate as a daytime indicator, ("Expectation-Maximization Binary Clustering for Behavioural Annotation").

Predictors can be converted to one or more numeric
    representations using a variety of methods. Effect encodings using
    simple generalized linear models <arXiv:1611.09477> or nonlinear
    models <arXiv:1604.06737> can be used.  There are also functions for
    dimension reduction and other approaches.

Provides a smooth mapping of multidimensional points into
    low-dimensional space defined by a self-organizing map. Designed to work
    with 'FlowSOM' and flow-cytometry use-cases. See Kratochvil et al. (2019)
    <doi:10.12688/f1000research.21642.1>.