Power Enhancement for High-Dimensional Mediation Analysis R package POEMED version 1.0.0 Provides powerful global tests for high-dimensional mediation analysis with heterogeneous (and even contrasting) mediation effects, for continuous, binary, and count outcomes. The power enhancement (PE) idea augments a Wald test on the total indirect effect with a component that captures marginal signals from individual mediators, so that active mediators are detected even when their individual indirect effects cancel and the total indirect effect is zero. The package also identifies which individual mediators are active with familywise error rate or false discovery rate control. The methods implement Yu and Kelley (in press), "Power Enhancement in High-Dimensional Heterogeneous Mediation Analysis" (Journal of the American Statistical Association); the package also simulates mediation data under the homogeneous, heterogeneous, and contrasting patterns that the article studies, ships its empirical health-expenditure data as a benchmark and reruns that empirical analysis, and runs the designs of its Monte Carlo size and power studies. The name, 'POEMED', from POwer-Enhanced MEDiation, encodes the method. Every estimation and testing function returns a tidy 'data.frame' that prints with sensible rounding and composes with the broader R ecosystem. Software Depends: R (>= 4.1.0) Imports: generics, glmnet, graphics, ncvreg, parallel, stats, utils, withr (>= 3.0.3) Suggests: knitr, rmarkdown, testthat (>= 3.2.0), tools Ken Kelley <kkelley@nd.edu> Comprehensive R Archive Network (CRAN) Xiufan Yu [aut], Ken Kelley [aut, cre] (ORCID: <https://orcid.org/0000-0002-4756-8360>) GPL (>= 3) 2026-10-18 application/tgz https://CRAN.R-project.org/package=POEMED doi:10.32614/CRAN.package.POEMED en-US