Optimal Hyperrectangular Operating Regions R package OptOR version 0.1.0 Computes optimal axis-aligned hyperrectangles for discrete binary arrays and continuous regions defined by quadratic response functions. The package provides methods for discrete optimization, grid classification, continuous refinement, and exact global extrema calculations. Applications include the identification of practical operating regions within multivariate design spaces, including pharmaceutical development settings related to ICH Q8. Software Imports: stats Suggests: ggplot2, grid, knitr, rmarkdown, testthat (>= 3.0.0) Christian Palmes <christian.palmes@bayer.com> Comprehensive R Archive Network (CRAN) Christian Palmes [aut, cre], Bayer AG [cph], Raluca Ilinca Schmitt [ctb], Adrian Funke [ctb] MIT + file LICENSE (https://CRAN.R-project.org/package=OptOR/LICENSE) 2026-09-12 application/tgz https://CRAN.R-project.org/package=OptOR doi:10.32614/CRAN.package.OptOR en-US