<?xml version="1.0" encoding="UTF-8"?>
<oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:title>Machine Learning Imputation, Clustering and Survival Analysis
for Longitudinal Proteomic Data</dc:title>
  <dc:title>R package MIML version 0.1.0</dc:title>
  <dc:description>Imputes missing biomarker measurements in a wide longitudinal
    serum panel with gradient-boosted decision trees, groups the completed
    panel by Bayesian consensus clustering, and compares the resulting patient
    subgroups by Kaplan-Meier, log-rank and Cox analysis. The imputation
    learner is described in Ke et al. (2017)
    &lt;https://papers.nips.cc/paper/6907-lightgbm-a-highly-efficient-gradient-boosting-decision-tree&gt;
    and the clustering method in Lock and Dunson (2013)
    &lt;doi:10.1093/bioinformatics/btt425&gt;. Imputed values are conditional-mean
    predictions, so the procedure is a machine-learning single imputation; the
    completions carry no between-imputation variance and must not be pooled by
    Rubin's rules. Two panels from Gene Expression Omnibus accession
    'GSE65622' are included, one for each survival endpoint.</dc:description>
  <dc:type>Software</dc:type>
  <dc:relation>Depends: R (&gt;= 4.1.0)</dc:relation>
  <dc:relation>Imports: lightgbm (&gt;= 3.3.0), data.table, survival, stats, utils</dc:relation>
  <dc:relation>Suggests: BCClong, testthat (&gt;= 3.0.0)</dc:relation>
  <dc:creator>Neelesh Kumar &lt;neelesh2302@gmail.com&gt;</dc:creator>
  <dc:publisher>Comprehensive R Archive Network (CRAN)</dc:publisher>
  <dc:contributor>Neelesh Kumar [aut, cre],
  Atanu Bhattacharjee [aut],
  Gajendra K. Vishwakarma [aut],
  Tanmoy Majumdar [aut]</dc:contributor>
  <dc:rights>GPL-3</dc:rights>
  <dc:date>2026-09-30</dc:date>
  <dc:format>application/tgz</dc:format>
  <dc:identifier>https://CRAN.R-project.org/package=MIML</dc:identifier>
  <dc:identifier>doi:10.32614/CRAN.package.MIML</dc:identifier>
</oai_dc:dc>
